کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6259685 | 1289997 | 2011 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Research reportPhysical activity and neural correlates of aging: A combined TMS/fMRI study Research reportPhysical activity and neural correlates of aging: A combined TMS/fMRI study](/preview/png/6259685.png)
Aerobic exercise has been suggested to ameliorate aging-related decline in humans. Recently, evidence has indicated chronological aging is associated with decreases in measures of interhemispheric inhibition during unimanual movements, but that such decreases may be mitigated by long-term physical fitness. The present study investigated measures of ipsilateral (right) primary motor cortex activity during right-hand movements using functional magnetic resonance imaging and transcranial magnetic stimulation (TMS). Healthy, right-handed participant groups were comprised of 12 sedentary older adults, 12 physically active older adults, and 12 young adults. Active older adults and younger adults evidenced longer ipsilateral silent periods (iSP) and less positive BOLD of ipsilateral motor cortex (iM1) as compared to sedentary older adults. Across groups, duration of iSP from TMS was inversely correlated with BOLD activity in iM1 during unimanual movement. These findings suggest that increased physical activity may have a role in decreasing aging-related losses of interhemispheric inhibition.
⺠We compare ipsilateral motor activity across age groupings using fMRI and TMS. ⺠Groups consist of young adults, physically active elderly adults, and sedentary elderly adults. ⺠Physically active older adults show ipsilateral motor patterns similar to younger adults. ⺠Ipsilateral silent period inversely correlates with fMRI activity in ipsilateral motor cortex.
Journal: Behavioural Brain Research - Volume 222, Issue 1, 12 September 2011, Pages 158-168