Network topology and dynamics in traumatic brain injury

- We propose a network approach to understanding behavioral phenotypes of traumatic brain injury (TBI).
- We review emerging TBI interventions from cognitive neuroscience.
- Findings motivate new perspectives about network dysfunction and rehabilitation in TBI.

We propose a network approach to clinical translation that defines core behavioral phenotypes of traumatic brain injury (TBI) with respect to damage to specific intrinsic connectivity networks (ICNs). We survey recent approaches to clinical translation from cognitive neuroscience that enhance network function and recovery from brain injury through interventions that deliver targeted (network specific) and global (systemic) effects. A network approach provides insight into the mechanisms of brain injury, linking ICN characteristics to specific profiles of cognitive impairment, providing key neurobiological targets for therapeutic intervention, and motivating new perspectives about the nature of cognitive recovery and rehabilitation in TBI.