کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6261617 | 1613232 | 2016 | 7 صفحه PDF | دانلود رایگان |
- Local resveratrol injection suppresses nociceptive SpVc WDR neuronal excitability.
- Neuronal firing rates were dose-dependently inhibited by resveratrol.
- The inhibitory effect of resveratrol lasted for 20Â min and was reversible.
- The potency of inhibition by resveratrol almost equaled that of 1% lidocaine.
- Resveratrol may be an effective treatment option for trigeminal pain.
Although we recently reported that intravenous administration of resveratrol suppresses trigeminal nociception, the precise peripheral effect of resveratrol on nociceptive and non-nociceptive mechanical stimulation-induced trigeminal neuron activity in vivo remains to be determined. The aim of the present study was to investigate whether local subcutaneous administration of resveratrol attenuates mechanical stimulation-induced excitability of trigeminal spinal nucleus caudalis (SpVc) neuron activity in rats, in vivo. Extracellular single-unit recordings were made of SpVc wide-dynamic range (WDR) neuron activity in response to orofacial mechanical stimulation in pentobarbital-anesthetized rats. Neurons responded to non-noxious and noxious mechanical stimulation applied to the orofacial skin. Local subcutaneous administration of resveratrol (1-10Â mM) into the orofacial skin dose dependently and significantly reduced the mean number of SpVc WDR neurons firing in response to both non-noxious and noxious mechanical stimuli, with the maximal inhibition of discharge frequency in response to both stimuli being seen within 5Â min. These inhibitory effects were no longer evident after approximately 20Â min. The mean magnitude of inhibition by resveratrol (10Â mM) of SpVc neuron discharge frequency was almost equal to that of the local anesthetic 1% lidocaine (37Â mM). These results suggest that local injection of resveratrol into the peripheral receptive field suppresses the excitability of SpVc neurons, possibly via inhibition of Na+ channels in the nociceptive nerve terminals of trigeminal ganglion neurons. Therefore, local subcutaneous administration of resveratrol may provide relief of trigeminal nociceptive pain, without side effects, thus contributing to the suite of complementary and alternative medicines used as local anesthetic agents.
Journal: Brain Research Bulletin - Volume 124, June 2016, Pages 262-268