Early-life stress and neurometabolites of the hippocampus

►Left medial temporal lobe (MTL) NAA/Choline decreased in monkeys subject to early-life stress. ►Right MTL NAA was positively associated with body mass. ►Left NAA/Choline decrease was due to independently low NAA and high Choline. ►Early-life stress correlated with asymmetrical MTL NAA changes (left < right) ►NAA reduction may reflect low neuronal viability of the hippocampus following early life stress.