کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6265666 | 1614192 | 2009 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Proximal colon distension induces Fos expression in oxytocin-, vasopressin-, CRF- and catecholamines-containing neurons in rat brain
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کلمات کلیدی
CRFNTSAVPDMVDVCarginine-vasopressin - آرژنین واسپرسینoxytocin - اکسیتوسینtyrosine hydroxylase - تیروزین هیدروکسیلازVisceral pain - درد احشاییarea postrema - طبقه آخرSON - فرزند پسرlocus coeruleus - لوکوس سیرولئوسPVN - مالیات بر ارزش افزودهdorsal vagal complex - مجتمع وگال پشتیventrolateral medulla - مدول ونتیلاتورSupraoptic nucleus - هسته Supraopticnucleus of the solitary tract - هسته دستگاه انفرادیdorsal motor nucleus of the vagus - هسته موتور پشتی وحشیparaventricular nucleus of the hypothalamus - هسته پروانه مرکزی هیپوتالاموسvasopressin - وازوپرسینcorticotrophin-releasing factor - کورتیکوتروپین آزاد کننده فاکتور
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Little is known about the chemical coding of the brain neuronal circuitry activated by nociceptive signals of visceral origin. We characterized brain nuclei activated during isovolumetric phasic distension of the proximal colon (10Â ml, 30Â s on/off for 10Â min) in conscious male rats, using Fos as a marker of neuronal activation and dual immunohistochemistry to visualize co-localization of Fos expression and oxytocin (OT), arginine-vasopressin (AVP), corticotrophin-releasing factor (CRF) or tyrosine hydroxylase (TH). Proximal colon distension, compared with sham distension, induced a robust increase in Fos-like immunoreactive (IR) neurons in the paraventricular nucleus (PVN), supraoptic nucleus (SON) and accessory neurosecretory nuclei of the hypothalamus, nucleus of the solitary tract (NTS) and ventrolateral medulla (VLM), and to a lower extent, in the locus coeruleus (LC) and Barrington nucleus. Fos-IR neurons in the PVN after colon distension were identified in 81% of OT-IR, 18% AVP-IR and 16% CRF-IR neurons, while in the SON it represented 36% of OT-IR and 16% AVP-IR. Catecholaminergic cell groups in the pons (LC) and medulla (VLM, NTS) were also activated by proximal colon distension. Of the TH-IR neurons in VLM and NTS, 74% and 42% respectively were double labeled. These results indicate that colon distension stimulates OT-, AVP- and CRF-containing hypothalamic neurons, likely involved in the integration of colonic sensory information to modulate autonomic outflow and pain-related responses. Activation of medullary catecholaminergic centers might reflect the afferent and efferent limbs of the functional responses associated to visceral pain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1247, 9 January 2009, Pages 79-91
Journal: Brain Research - Volume 1247, 9 January 2009, Pages 79-91
نویسندگان
Lixin Wang, Vicente MartÃnez, Muriel Larauche, Yvette Taché,