کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6270977 | 1614746 | 2016 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Short-term immobilization influences use-dependent cortical plasticity and fine motor performance
ترجمه فارسی عنوان
کوتاه مدت بی حرکت شدن تاثیری بر پلاستیک کورتیک وابسته و عملکرد موتور خوب دارد
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کلمات کلیدی
MmaxMEPICFLICIBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز ISI - آی اس آیFirst Dorsal Interosseous - ابتدای پشتی بینهایتgamma-aminobutyric acid - اسید گاما آمینو بوتیریکlong-term depression - افسردگی طولانی مدتelectromyography - الکترومیوگرافیEMG - الکترومیوگرافیIntracortical facilitation - تسهیل درون کوهیlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP FDI - سرمایهگذاری مستقیم خارجیInterstimulus interval - فاصله بین فاصلهBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزLTD - محدودlong-interval intracortical inhibition - مهار بی حرکتی طولانی مدتmotor-evoked potential - پتانسیل حرکت موتورGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Short-term immobilization that reduces muscle use for 8-10Â h is known to influence cortical excitability and motor performance. However, the mechanisms through which this is achieved, and whether these changes can be used to modify cortical plasticity and motor skill learning, are not known. The purpose of this study was to investigate the influence of short-term immobilization on use-dependent cortical plasticity, motor learning and retention. Twenty-one adults were divided into control and immobilized groups, both of which underwent two experimental sessions on consecutive days. Within each session, transcranial magnetic stimulation (TMS) was used to assess motor-evoked potential (MEP) amplitudes, short- (SICI) and long-interval intracortical inhibition (LICI), and intracortical facilitation (ICF) before and after a grooved pegboard task. Prior to the second training session, the immobilized group underwent 8Â h of left hand immobilization targeting the index finger, while control subjects were allowed normal limb use. Immobilization produced a reduction in MEP amplitudes, but no change in SICI, LICI or ICF. While motor performance improved for both groups in each session, the level of performance was greater 24-h later in control, but not immobilized subjects. Furthermore, training-related MEP facilitation was greater after, compared with before, immobilization. These results indicate that immobilization can modulate use-dependent plasticity and the retention of motor skills. They also suggest that changes in intracortical excitability are unlikely to contribute to the immobilization-induced modification of cortical excitability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 330, 25 August 2016, Pages 247-256
Journal: Neuroscience - Volume 330, 25 August 2016, Pages 247-256
نویسندگان
George M. Opie, Alexandra Evans, Michael C. Ridding, John G. Semmler,