کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6271266 1614754 2016 21 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neural stem/progenitor cell transplantation for spinal cord injury treatment; A systematic review and meta-analysis
ترجمه فارسی عنوان
پیوند سلول های ساقه عصبی / پیش داوری برای درمان صدمات نخاعی؛ بررسی منظم و متا آنالیز
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Despite the vast improvements of cell therapy in spinal cord injury treatment, no optimum protocol has been developed for application of neural stem/progenitor cells. In this regard, the present meta-analysis showed that the efficacy of the neural stem/progenitor cell (NSPC) transplantation depends mainly on injury model, intervention phase, transplanted cell count, immunosuppressive use, and probably stem cell source. Improved functional recovery post NSPC transplantation was found to be higher in transection and contusion models. Moreover, NSPC transplantation in acute phase of spinal injury was found to have better functional recovery. Higher doses (>3 × 106 cell/kg) were also shown to be optimum for transplantation, but immunosuppressive agent administration negatively affected the motor function recovery. Scaffold use in NSPC transplantation could also effectively raise functional recovery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 322, 13 May 2016, Pages 377-397
نویسندگان
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