کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6271370 | 1614757 | 2016 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Blast exposure causes dynamic microglial/macrophage responses and microdomains of brain microvessel dysfunction
ترجمه فارسی عنوان
قرار گرفتن در معرض انفجار باعث پاسخ های میکروگلالی / ماکروفاژ پویا و اختلال عملکرد میکروویروس مغز می شود
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کلمات کلیدی
DABBOPmTBIGFPSPFCTEPBSMild traumatic brain injury - آسیب مغزی آسیبدیده خفیفchronic traumatic encephalopathy - انسفالوپاتی مزمن ترومایتیBlast overpressure - انفجار انفجارdiaminobenzidine - دیامینو بنزیدینBBB - سد خونی مغزیBlood–brain barrier - سد خونی مغزیMacrophages - ماکروفاژها،درشت خوارهاPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریTwo-photon microscopy - میکروسکوپ دو فوتونMicroglia - میکروگلیاهاneuropathology - نوروپاتولوژی یا آسیب شناسی عصبیgreen fluorescent protein - پروتئین فلورسنت سبز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Exposure to blast overpressure (BOP) is associated with behavioral, cognitive, and neuroimaging abnormalities. We investigated the dynamic responses of cortical vasculature and its relation to microglia/macrophage activation in mice using intravital two-photon microscopy following mild blast exposure. We found that blast caused vascular dysfunction evidenced by microdomains of aberrant vascular permeability. Microglial/macrophage activation was specifically associated with these restricted microdomains, as evidenced by rapid microglial process retraction, increased ameboid morphology, and escape of blood-borne Q-dot tracers that were internalized in microglial/macrophage cell bodies and phagosome-like compartments. Microdomains of cortical vascular disruption and microglial/macrophage activation were also associated with aberrant tight junction morphology that was more prominent after repetitive (3Ã) blast exposure. Repetitive, but not single, BOPs also caused TNFα elevation two weeks post-blast. In addition, following a single BOP we found that aberrantly phosphorylated tau rapidly accumulated in perivascular domains, but cleared within four hours, suggesting it was removed from the perivascular area, degraded, and/or dephosphorylated. Taken together these findings argue that mild blast exposure causes an evolving CNS insult that is initiated by discrete disturbances of vascular function, thereby setting the stage for more protracted and more widespread neuroinflammatory responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 319, 5 April 2016, Pages 206-220
Journal: Neuroscience - Volume 319, 5 April 2016, Pages 206-220
نویسندگان
B.R. Huber, J.S. Meabon, Z.S. Hoffer, J. Zhang, J.G. Hoekstra, K.F. Pagulayan, P.J. McMillan, C.L. Mayer, W.A. Banks, B.C. Kraemer, M.A. Raskind, D.B. McGavern, E.R. Peskind, D.G. Cook,