کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6271646 | 1614765 | 2015 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prenatal binge-like alcohol exposure alters brain and systemic responses to reach sodium and water balance
ترجمه فارسی عنوان
قرار گرفتن در معرض الکل مانند آلزایمر مانند مجاری مغز، پاسخ مغزی و سیستمیک را برای رسیدن به تعادل سدیم و آب تغییر می دهد
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کلمات کلیدی
diaminobenzidine hydrochloridePAMMPDNDRV5-HT-IRMNPOOVLTCVOsNHSDABLPBNAVPNTSDRNSFO5HTCeA - CEAorganum vasculosum of the lamina terminalis - ارگانواسکوئوزوم ترمینال لامیناsodium appetite - اشتها سدیمcircumventricular organs - اندامهای دور رحمیImmunoreactivity - ایمنی فعالphosphate buffer - بافر فسفاتSodium balance - تعادل سدیمFURO - حلقهgestational day - روز بارداریpostnatal day - روز پس از زایمانSodium - سدیم normal horse serum - سرم طبیعی اسبSerotonergic system - سیستم سروتونرژیکarea postrema - طبقه آخرSubfornical organ - عضو زیربنیکیSON - فرزند پسرfurosemide - فوروزمایدPrenatal ethanol exposure - قرار گرفتن در معرض اتانول پیش از قاعدگیPVN - مالیات بر ارزش افزودهPalm - نخلSerotonergic neurons - نورونهای سروتونرژیکSupraoptic nucleus - هسته Supraopticnucleus of the solitary tract - هسته دستگاه انفرادیdorsal raphe nucleus - هسته رافهcentral amygdaloid nucleus - هسته مرکزی amygdaloidparaventricular nucleus - هسته پروژسترویکmedian preoptic nucleus - هسته پیشوپتیک مدیاستveh - وایVehicle - وسیله نقلیهSodium depletion - کاهش سدیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
The aim of the present work is to analyze how prenatal binge-like ethanol exposure to a moderate dose (2.0Â g/kg; group Pre-EtOH) during gestational days (GD) 17-20 affects hydroelectrolyte regulatory responses. This type of exposure has been observed to increase ethanol consumption during adolescence (postnatal day 30-32). In this study we analyzed basal brain neural activity and basal-induced sodium appetite (SA) and renal response stimulated by sodium depletion (SD) as well as voluntary ethanol consumption as a function of vehicle or ethanol during late pregnancy. In adolescent offspring, SD was induced by furosemide and a low-sodium diet treatment (FUROÂ +Â LSD). Other animals were analyzed in terms of immunohistochemical detection of Fra-like (Fra-LI-ir) protein and serotonin (5HT) and/or vasopressin (AVP). The Pre-EtOH group exhibited heightened voluntary ethanol intake and a reduction in sodium and water intake induced by SD relative to controls. Basal Na and K concentrations in urine were also reduced in Pre-EtOH animals while the induced renal response after FURO treatment was similar across prenatal treatments. However, the correlation between urine volume and water intake induced by FURO significantly varied across these treatments. At the brain level of analysis, the number of basal Fra-LI-ir was significantly increased in AVP magnocellular neurons of the paraventricular nucleus (PVN) and in 5HT neurons in the dorsal raphe nucleus (DRN) in Pre-EtOH pups. In the experimental group, we also observed a significant increase in Fra-LI along the nucleus of the solitary tract (NTS) and in the central extended amygdala nuclei. In summary, moderate Pre-EtOH exposure produces long-lasting changes in brain organization, affecting basal activity of central extended amygdala nuclei, AVP neurons and the inhibitory areas of SA such as the NTS and the 5HT-DRN. These changes possibly modulate the above described variations in basal-induced drinking behaviors and renal regulatory responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 311, 17 December 2015, Pages 92-104
Journal: Neuroscience - Volume 311, 17 December 2015, Pages 92-104
نویسندگان
A. Godino, P. Abate, J.L. Amigone, L. Vivas, J.C. Molina,