کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6271698 | 1614765 | 2015 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prenatal valproic acid exposure disrupts tonotopic c-Fos expression in the rat brainstem
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کلمات کلیدی
DCNSPONPVCNMSOLNTBECICLSODCICAVCNPAGMNTBCNICAutism spectrum disorder - اختلالات طیف اوتیسم گروهیphosphate buffer - بافر فسفاتlateral - جانبیEmbryonic - جنینperiaqueductal gray - خاکستری پرآبیlateral superior olive - زیتون برتر جانبیmedial superior olive - زیتون عالیSOC - سیستم روی یک تراشهreticular formation - شکل گیری رتیکولFacial nerve - عصب صورتdorsal - عقبPosterior - عقبexternal cortex of the inferior colliculus - قشر خارجی کولیکولوس پایینdorsal cortex of the inferior colliculus - قشر پشتی کولیکولوس پایینsuperior olivary complex - مجتمع عالی ایلواریASD - نقص سپتوم یا دیوارهی دهلیزیlateral nucleus of the trapezoid body - هسته جانبی بدن بدنه استposterior ventral cochlear nucleus - هسته حلقوی شکمی خلفیanterior ventral cochlear nucleus - هسته حلقوی شکمی قدامیmedial nucleus of the trapezoid body - هسته مرکزی بدن تراپزیCentral Nucleus of the Inferior Colliculus - هسته مرکزی کولیکولوس پایینCochlear Nucleus - هسته کچلرdorsal cochlear nucleus - هسته کچلی پشتیInferior colliculus - کولیکولوس پایین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by difficulties with communication and social interactions, restricted, repetitive behaviors and sensory abnormalities. Additionally, the vast majority of subjects with ASD suffer some degree of auditory dysfunction and we have previously identified significant hypoplasia and dysmorphology in auditory brainstem centers in individuals with ASD. Prenatal exposure to the antiepileptic drug valproic acid (VPA) is associated with an increased risk of ASD. In rodents, prenatal exposure to VPA is utilized as an animal model of ASD and is associated with a number of anatomical, physiological and behavioral deficits, including hypoplasia and dysmorphology in the auditory brainstem. Based on these observations, we hypothesized that such dysmorphology in VPA-exposed animals would translate into abnormal activity in brainstem circuits and irregular tonotopic maps. Herein, we have subjected control and VPA-exposed animals to 4 or 16Â kHz tones and examined neuronal activation with immunohistochemistry for c-Fos. After these sound exposures, we found significantly more c-Fos-positive neurons in the auditory brainstem of VPA-exposed animals. Further, we found a larger dispersion of c-Fos-positive neurons and shifted tonotopic bands in VPA-exposed rats. We interpret these findings to suggest hyper-responsiveness to sounds and disrupted mapping of sound frequencies after prenatal VPA exposure. Based on these findings, we suggest that such abnormal patterns of activation may play a role in auditory processing deficits in ASD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 311, 17 December 2015, Pages 349-361
Journal: Neuroscience - Volume 311, 17 December 2015, Pages 349-361
نویسندگان
A. Dubiel, R.J. Kulesza,