کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6272851 | 1614789 | 2015 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Decreased anti-regenerative effects after spinal cord injury in spry4â/â mice
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کلمات کلیدی
DAPIRTKPBSFGFGFAPTNFα4′,6-diamidino-2-phenylindole - 4 '، 6-دیامیدینو-2-فنیلینولMAPK - MAPKAstrocytes - آستروسیتSpinal cord injury - آسیب نخاعیinflammation - التهاب( توروم) tumor necrosis factor α - تومور نکروز عامل αRTK, Receptor tyrosine kinase - تیروزین کینازهای گیرنده ایsci - علمیfibroblast growth factor - فاکتور رشد فیبروبلاستPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالmitogen-activated protein kinase - پروتئین کیناز فعال با mitogen
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Previously, we have demonstrated a role for fibroblast growth factor (Fgf) in spinal cord regeneration in both zebrafish and mouse. We have shown that exogenous Fgf2 treatment attenuates astrocytic gliosis and induces glia cells to become progenitors that undergo neurogenesis as well as differentiating into bipolar astrocytes that support axonal regeneration (Goldshmit et al., 2012, 2014). One of the downstream signaling target genes of Fgf is spry4, which acts as a feedback inhibitor for Fgf signaling. In this study we examined the effects of increased endogenous Fgf signaling, in spry4â/â mice, on the early events that occur after spinal cord injury (SCI). We demonstrate that in spry4â/â mice inflammatory responses, such as tumor necrosis factor α (TNFα) secretion and macrophage/neutrophil invasion into the lesion site are reduced. In addition, astrocytic gliosis is attenuated and neuronal survival is increased. These results further support a pro-regenerative role of Fgf after SCI, and suggest that increased endogenous Fgf signaling after SCI may contribute to functional recovery and therefore presents this pathway as a target for new therapy development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 287, 26 February 2015, Pages 104-112
Journal: Neuroscience - Volume 287, 26 February 2015, Pages 104-112
نویسندگان
Y. Goldshmit, F. Frisca, J. Kaslin, A.R. Pinto, J.-K.K.Y. Tang, A. Pébay, R. Pinkas-Kramarski, P.D. Currie,