کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6273283 | 1614794 | 2014 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neurotrophins in the ventral tegmental area: Role in social stress, mood disorders and drug abuse
ترجمه فارسی عنوان
نوروتروفین ها در ناحیه قلب تنگستن: نقش در استرس اجتماعی، اختلالات خلقی و سوء مصرف مواد
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کلمات کلیدی
MORPLC-γtVTATrkBVTAN-methyl-d-aspartateGDNFNMDANGFERKFGFPFCNACBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز MAPK - MAPKSocial stress - استرس اجتماعیDepression - افسردگیDrug abuse - سوء مصرف موادCross-sensitization - صلیب حساسیتnerve growth factor - فاکتور رشد عصبfibroblast growth factor - فاکتور رشد فیبروبلاستGlial cell line-derived neurotrophic factor - فاکتور نوروتروفی مشتق از سلول گلیاییBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزphospholipase C-γ - فسفولیپاز C-γprefrontal cortex - قشر prefrontalventral tegmental area - ناحیه تگمنتوم شکمیNeurotrophin - نوروتروفینNucleus accumbens - هسته accumbensmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولیmu-opioid receptor - گیرنده ی مئو-اپوئیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
This review discusses the impact of neurotrophins and other trophic factors, including fibroblast growth factor and glial cell line-derived neurotrophic factor, on mood disorders, weight regulation and drug abuse, with an emphasis on stress- and drug-induced changes in the ventral tegmental area (VTA). Neurotrophins, comprising nerve growth factor, brain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4/5 play important roles in neuronal plasticity and the development of different psychopathologies. In the VTA, most research has focused on the role of BDNF, because other neurotrophins are not found there in significant quantities. BDNF originating in the VTA provides trophic support to dopamine neurons. The diverse intracellular signaling pathways activated by BDNF may underlie precise physiological functions specific to the VTA. In general, VTA BDNF expression increases after psychostimulant exposures, and enhanced BDNF level in the VTA facilitates psychostimulant effects. The impact of VTA BDNF on the behavioral effects of psychostimulants relies primarily on its action within the mesocorticolimbic circuit. In the case of opiates, VTA BDNF expression and effects seem to be dependent on whether an animal is drug-naïve or has a history of drug use, only the latter of which is related to dopamine mechanisms. Social defeat stress that is continuous in mice or intermittent in rats increases VTA BDNF expression, and is associated with depressive and social avoidance behaviors. Intermittent social defeat stress induces persistent VTA BDNF expression that triggers psychostimulant cross-sensitization. Understanding the cellular and molecular substrates of neurotrophin effects may lead to novel therapeutic approaches for the prevention and treatment of substance use and mood disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 282, 12 December 2014, Pages 122-138
Journal: Neuroscience - Volume 282, 12 December 2014, Pages 122-138
نویسندگان
E.M. Nikulina, C.E. Johnston, J. Wang, R.P. Jr.,