ReviewWhite matter plasticity in adulthood

- We review the changes that occur within the CNS white matter over the lifetime.
- We highlight significant gaps in our current understanding of myelin plasticity.
- We explore the purpose of internode addition to the normal adult and aged CNS.

CNS white matter is subject to a novel form of neural plasticity which has been termed “myelin plasticity”. It is well established that oligodendrocyte generation and the addition of new myelin internodes continue throughout normal adulthood. These new myelin internodes maybe required for the de novo myelination of previously unmyelinated axons, myelin sheath replacement, or even myelin remodeling. Each process could alter axonal conduction velocity, but to what end? We review the changes that occur within the white matter over the lifetime, the known regulators and mediators of white matter plasticity in the mature CNS, and the physiological role this plasticity may play in CNS function.

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