کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6274910 | 1614836 | 2013 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
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کلمات کلیدی
PBS1-methyl-4-phenylpyridinium iodideSH-SY5YFCSMPTPPFAPPARDPBSGFAPTNFαDMEM1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridineDMSO - DMSODulbecco’s modified Eagle medium - Modified Eagle اصلاح شده DulbeccoMPP+ - MPP +MTT - MTTEDTA - اتیلن دی آمین تترا استیک اسید Ethylenediaminetetraacetic acid - اتیلینیدامین تتراستیک اسیدNeuroinflammation - التهاب عصبیinterleukin - اینترلوکینParkinson’s disease - بیماری پارکینسونNeurodegeneration - تولید نوروژنیکtumour necrosis factor-α - تومور نکروز عامل αtyrosine hydroxylase - تیروزین هیدروکسیلازDimethyl sulfoxide - دیمتیل سولفواکسیدfoetal calf serum - سرم گوساله جنینdulbecco’s phosphate-buffered saline - فسفات باسیل نمک dulbeccolactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH Phosphate-buffered saline - محلول نمک فسفات با خاصیت بافریMac-1 - مک 1paraformaldehyde - پارافرمالدهیدglial fibrillary acid protein - پروتئین اسید فیبریلیری گلیالperoxisome proliferator-activated receptor - گیرنده فعال فعال پروکسیوم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease](/preview/png/6274910.png)
چکیده انگلیسی
Peroxisome proliferator-activated receptor (PPAR)-γ and PPARα have shown neuroprotective effects in models of Parkinson's disease (PD). The role of the third, more ubiquitous isoform PPARδ has not been fully explored. This study investigated the role of PPARδ in PD using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to model the dopaminergic neurodegeneration of PD. In vitro administration of the PPARδ antagonist GSK0660 (1 μM) increased the detrimental effect of 1-methyl-4-phenylpyridinium iodide (MPP+) on cell viability, which was reversed by co-treatment with agonist GW0742 (1 μM). GW0742 alone did not affect MPP+ toxicity. PPARδ was expressed in the nucleus of dopaminergic neurons and in astrocytes. Striatal PPARδ levels were increased (over two-fold) immediately after MPTP treatment (30 mg/kg for 5 consecutive days) compared to saline-treated mice. PPARδ heterozygous mice were not protected against MPTP toxicity. Intra-striatal infusion of GW0742 (84 μg/day) reduced the MPTP-induced loss of dopaminergic neurons (5036 ± 195) when compared to vehicle-infused mice (3953 ± 460). These results indicate that agonism of PPARδ provides protection against MPTP toxicity, in agreement with the effects of other PPAR agonists.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 240, 14 June 2013, Pages 191-203
Journal: Neuroscience - Volume 240, 14 June 2013, Pages 191-203
نویسندگان
H.L. Martin, R.B. Mounsey, K. Sathe, S. Mustafa, M.C. Nelson, R.M. Evans, P. Teismann,