How adenylate cyclase choreographs the pas de deux of the receptors heteromerization dance

► Heteromers form through electrostatic interactions of linear motifs located in disordered regions of receptors' proteins. ► Activation/inhibition of adenylate cyclase by Adenosine/Dopamine controls the production of cAMP which activates PKA. ► Phosphorylation of Ser/Thr by cAMP-activated PKA in the Arginine-rich epitope controls the stability of heteromers. ► Dopaminergic neurotransmission, through cAMP-dependent PKA slows down heteromerization. ► In heteromerization, phosphorylation is not just an on/off switch, by weakening noncovalent bonds, it acts like a rheostat.