Lack of influence of prion protein gene expression on kainate-induced seizures in mice: Studies using congenic, coisogenic and transgenic strains

► PrP knockout partially reduces kainate seizure sensitivity in C57BL/10SnJ mice. ► Reintroduction of PrP-transgene in knockout fails to restore original phenotype. ► PrP knockout in coisogenic 129 mice slightly increases kainate seizure sensitivity.