The ubiquitin ligase F-box/G-domain protein 1 promotes the degradation of the disease-linked protein torsinA through the ubiquitin-proteasome pathway and macroautophagy

► FBG1 promotes torsinA degradation. ► FBG1 acts through both the proteasome and autophagy. ► The N-terminal domain of FBG1 is key for its functional versatility. ► Absence of FBG1 triggers age-related motor dysfunction in torsinA(ΔE) knock-in mice.