Keywords: ناک اوت; TNF; Cytoskeleton; IBD; Immune Response; AIEC; adherent-invasive E coli; CD; Crohn's disease; DAMP; damage-associated molecular patterns; DKO; double knock out; DNML1; dynamin1 like; DTT; dithiothreitol; EGFP; enhanced green fluorescent protein; EIF2A;
مقالات ISI ناک اوت (ترجمه نشده)
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Keywords: ناک اوت; Demencia; EncefalopatÃa; Knock out; Adolescente; Deportivo; PugilÃstica; Dementia; Encefalopathy; Knock out; Adolescent; Sports; Boxing;
Keywords: ناک اوت; CD8 T cell; Antigen processing; Proteasome; MHC class I; Dermal DNA tattoo immunization; DTR; diphtheria toxin receptor (DTR); KO; knock out; LC; Langerhans cell; KI; knock in; WT; wild type;
Keywords: ناک اوت; AC; Adenylyl cyclase; cAMP; Cyclic AMP; SDS-PAGE; Sodium dodecyl sulfate-polyacrylamide gel electrophoresis; DKO; Double knock out; KO; Knock out; PMSF; phenylmethylsulfonyl fluoride; GppNHp; Guanosine 5â²-[β,γ-imido]triphosphate; Adenylyl cyclase; Rec
Keywords: ناک اوت; Estrogen; Neuroprotection; Aging; Cognition; Stroke; Traumatic brain injury; 3NPA; 3-nitropropionic acid; 17αE2; 17 alpha-estradiol; 17βE2; 17 beta-estradiol; ATP; adenosine triphosphate; BBB; blood brain barrier; BDNF; brain-derived neurotrophic factor
Keywords: ناک اوت; CPM; counts per minute; CV; coefficient of variation; DPBS; dulbecco's phosphate-buffered saline; EDTA; ethylenediaminetetraacetic acid; KO; knock out; mRNA; messenger ribonucleic acid; RIA; radioimmunoassay; qPCR; quantitative real-time polymerase chai
Keywords: ناک اوت; BAC; bacterial artificial chromosome; bp; base pair; CNS; central nervous system; ES; embryonic stem; IL-5Rα; interleukin-5 receptor α subunit; KO; knock out; L-LP; large intestinal lamina propria; LP; lamina propria; PC; peritoneal cavity; PDZ; PSD-95/
Keywords: ناک اوت; Dendritic spine; Synaptic plasticity; Neurodegenerative diseases; Psychiatric disorders; Glutamate receptor; Calcium signaling; ADHD; attention deficit hypersensitive disorders; FXS; Fragile X-syndrome; CNS; central nervous system; GABA; gamma amino butyr
Keywords: ناک اوت; ACC; anterior cingulate cortex; AMPA; alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived neurotrophic factor; CaMKII; Ca2+/calmodulin-dependent protein kinase II; cAMP; cyclic adenosine monophosphate; CREB; cAMP-response elemen
AKT1 distinctively suppresses MyD88-depenedent and TRIF-dependent Toll-like receptor signaling in a kinase activity-independent manner
Keywords: ناک اوت; TLR; Toll-like receptor; TRIF; Toll/IL-1R domain-containing adaptor inducing IFN-β; LPS; lipopolysaccharide; KD; kinase-dead; IRAK; IL-1R-associated kinase; ISG; interferon stimulated gene; PIP3; phosphatidylinositol (3,4,5) trisphosphate; PH; pleckstrin
PK2β ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through PKR1 receptor
Keywords: ناک اوت; Prokineticin 2β; Prokineticin receptors; G protein coupled receptor; Yeast-STAT3; Thermal hyperalgesia; Tactile allodynia; GPCR; G Protein-Coupled Receptor; PK; Prokineticin; PKR; Prokineticin Receptor; PK2β; Prokineticin 2β; ERK; Extracellular signal-
Deleting MyD88 signaling in myeloid cells promotes development of adenocarcinomas of the colon
Keywords: ناک اوت; MyD88; Myeloid cells; Colitis-associated colorectal cancer; Chronic inflammation; Azoxymethane; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3 related; MMP10; metalloproteinase10; Cox-2; cyclooxygenase-2; Hif-1α; hypoxia-inducibl
Strategies for controlling CRISPR/Cas9 off-target effects and biological variations in mammalian genome editing experiments
Keywords: ناک اوت; CRISPR; clustered regularly interspaced short palindromic repeats; gRNA; guide RNA; OTE; off-target effects; KO; knock out; NHEJ; non-homologous end joining; KI; knock in; HDR; homology directed repair; GOI; gene of interest; LOI; locus of interest; iPSC;
β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573
Keywords: ناک اوت; ARVM; adult rat ventricular myocytes; CaMKII; calcium/calmodulin-dependent kinase II; cMyBP-C; cardiac myosin binding protein-C; cTnI; cardiac troponin I; I-1; inhibitor of protein phosphatase-1; ISO; isoprenaline; KO; knock out; MOI; multiplicity of infe
The ATP-stimulated translocation promoter (ASTP) activity of glycerol kinase plays central role in adipogenesis
Keywords: ناک اوت; Glycerol kinase; Glycerol kinase deficiency; Metabolic flux analysis; Moonlighting proteins; Adipogenesis; ASTP; ATP stimulated translocation promoter; GK; glycerol kinase; GKD; glycerol kinase deficiency; VDAC; voltage-dependent anion channel; Gyk; murin
UTX - moonlighting in the cytoplasm?
Keywords: ناک اوت; NLS; nuclear localization signal; Ko; knock out; Wt; wild type; UTX; Histone; Demethylase; Demethylase-independent; Localization; NLS; UTY;
The interaction of IGF-1/IGF-1R and hydrogen sulfide on the proliferation of mouse primary vascular smooth muscle cells
Keywords: ناک اوت; BrdU; bromodeoxyuridine; CBS; cystathionine-beta-synthase; CRISPR; clustered regularly interspaced short palindromic repeats; CSE; cystathionine-gamma-lyase; DMEM; dulbecco's modified eagle's medium; ERK; extracellular regulated protein kinase; FBS; f
Both perforin and FasL are required for optimal CD8 T cell control of autoreactive B cells and autoantibody production in parent-into-F1 lupus mice
Keywords: ناک اوت; Graft-vs.-host disease; T cells; Cytotoxicity; Lupus; aGVHD; acute GVHD; BDF1; B6D2F1; B6; C57Bl/6; cGVHD; chronic GVHD; FasL; Fas ligand; GVHD; graft -vs.-host disease; KO; knock out; pâF1; parent-into-F1; pfp; perforin; WT; wild type;
NRF2 mitigates acute alcohol-induced hepatic and pancreatic injury in mice
Keywords: ناک اوت; NRF2; Alcohol; Hepatic injury; Pancreatic injury; Alcoholism; ADH1; alcohol dehydrogenase 1; ALD; alcoholic liver disease; ALDH; aldehyde dehydrogenase; AMS; amylase; ALT; alanine transaminase; ARE; antioxidant response element; AST; aspartate aminotransf
H2S protects lipopolysaccharide-induced inflammation by blocking NFκB transactivation in endothelial cells
Keywords: ناک اوت; H2S; Cystathionine gamma-lyase; LPS; Endothelial cells; Inflammation; NFκB; ChIP; chromatin immunoprecipitation; CRISPR; clustered regulatory interspersed short palindromic repeats; CSE; Cystathionine gamma-lyase; H2S; Hydrogen sulfide; HUVEC; Human umbi
The activation of STIM1 mediates S-phase arrest and cell death in paraquat induced acute lung intoxication
Keywords: ناک اوت; ALI; acute lung injury; 2-APB; 2-Aminoethoxydiphenyl borate; BSA; bovine serum albumin; CCNA/CCND/Cyclin A/D; mammalian A/D-type Cyclin; CDK; Cyclin dependent kinase; CKI; Cyclin dependent kinase inhibitor; CRISPR-CAS9; clustered regularly interspaced sho
Non-redundant role of the chemokine receptor CX3CR1 in the anti-inflammatory function of gut macrophages
Keywords: ناک اوت; CNS; central nervous system; DC; dendritic cells; D.A.I.; disease activity index; DSS; dextran sulphate sodium; GFP; green fluorescent protein; IL-10R; IL-10 receptor; KO; knock out; MLN; mesenteric lymph nodes; MÏ; macrophages; OVA; ovalbumin; Macrophag
Dual antiplasmodial activity of vitamin D3 and its analog, 22-oxacalcitriol, by direct and indirect mechanisms
Keywords: ناک اوت; VD3; vitamin D3, (1α,25-dihydroxyvitamin D3); VD; vitamin D; VDR; vitamin D receptor; KO; knock out; ZA; zoledronic acid; IFN-γ; interferon gamma; 22-OCT; 22-oxacalcitriol; PcAS; Plasmodium chabaudi AS; Pf; Plasmodium falciparum; PRBCs; parasitized red
Research PaperReggie-1 and reggie-2 (flotillins) participate in Rab11a-dependent cargo trafficking, spine synapse formation and LTP-related AMPA receptor (GluA1) surface exposure in mouse hippocampal neurons
Keywords: ناک اوت; CA; constitutive active; ECS; extracellular solution; EGFP; enhanced green fluorescent protein; EHD; Eps15 homology domain-containing proteins; Flot2; flotillin-2; k.o.; knock out; LTP; long term potentiation; MAPK; mitogen-activated kinase; div; days in
CRISPR knock out CTLA-4 enhances the anti-tumor activity of cytotoxic T lymphocytes
Keywords: ناک اوت; CRISPR-Cas9; Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9; CTLA-4; cytotoxic T-lymphocyte-associated protein 4; KO; knock out; CTL; cytotoxic T lymphocytes; TNF-α; Tumor necrosis factor-α; IFN-γ; interferon
shRNA interference of NLRP3 inflammasome alleviate ischemia reperfusion-induced myocardial damage through autophagy activation
Keywords: ناک اوت; sh-NLRP3; Ischemia reperfusion; Myocardial damage; Autophagy; I/R; ischemia-reperfusion; SD; Sprague-Dawley; KO; knock out; NLRP3; nod-like receptor protein 3; IL; interleukin; TNF-α; tumor necrosis factor α; HE; Hematoxylin and Eosin; WT; wild type; TU
Ablation of IL-33 gene exacerbate myocardial remodeling in mice with heart failure induced by mechanical stress
Keywords: ناک اوت; IL-33; Cardiac remodeling; Hypertrophy; Fibrosis; TAC; AP-1; activator protein 1; BW; body weight; EF; ejection fraction; FS; fractional shortening; H&E; hematoxylin and eosin; HF; heart failure; HW; heart weight; HW/BW; heart weight to body weight; HW/TL
Nitric oxide/cGMP signaling via guanylyl cyclase isoform 1 modulates glutamate and GABA release in somatosensory cortex of mice
Keywords: ناک اوت; 8-Br-PET-cGMP; 8-Bromo-β-phenyl-1, N2-ethenoguanosine-cGMP; ACSF; artificial cerebrospinal fluid; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; cGMP; cyclic guanosine monophosphate; D-AP5; d-(-)-2-amino-5-phosphonopentanoic aci
Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria
Keywords: ناک اوت; Mevalonic aciduria; Mevalonate kinase deficiency; Mevalonic acid; Mevalonolactone; Mitochondrial function; Mitochondrial permeability transition; ACO; aconitase; Alm; alamethicin; BSA; bovine serum albumin; CAC; citric acid cycle; CCCP; carbonyl cyanide 3
In vivo IL-4 prevents allo-antigen driven CD8+ CTL development
Keywords: ناک اوت; Graft-vs.-host disease; T cells; IL-4; CTL; Mouse; Cytokine; BDF1; B6D2F1; B6; C57Bl/6; GrB; granzyme B; HVG; host-vs.-graft; KO; knock out; p â F1; parent-into-F1; pfp; perforin; Tfh; T follicular helper; WT; wild type;
Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus
Keywords: ناک اوت; SSTR5; somatostatin receptor subtype 5; OGTT; oral glucose tolerance test; hERG; human ether-a-go-go related gene; DM; diabetes mellitus; HFD; high-fat diet; NCS; N-chlorosuccinimide; WSC; 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride; HOB
The absence of 25-hydroxyvitamin D3-1α-hydroxylase potentiates the suppression of EAE in mice by ultraviolet light
Keywords: ناک اوت; MS; multiple sclerosis; CNS; central nervous system; BBUVB; broad band ultraviolet B; NBUVB; narrow band ultraviolet B; EAE; experimental autoimmune encephalomyelitis; CYP27B1; cytochrome p450 27B1; WT; wild type; KO; knock out; Multiple sclerosis; Experi
Phagocytosis of bone marrow derived macrophages is controlled by phosphoinositide 3-kinase γ
Keywords: ناک اوت; BMDM; bone marrow derived macrophages; PI3Kγ; phosphoinositide 3-kinase gamma; PAMP; pathogen associated molecular pattern; DAMP; damage associated molecular patterns; PKA; protein kinase A; PDE; phosphodiesterase; KO; knock out; KD; kinase dead; PI3Kγ;
E3 ubiquitin ligase NKLAM ubiquitinates STAT1 and positively regulates STAT1-mediated transcriptional activity
Keywords: ناک اوت; NKLAM; natural killer lytic-associated molecule; STAT1; signal transducer and activator of transcription 1; RBR; RING in between RING; JAK1; Janus kinase 1; IFNγ; interferon gamma; IFNGR; interferon gamma receptor; GAS; gamma interferon activation sequen
Large-scale gene expression profiling reveals physiological response to deletion of chaperone dnaKJ in Escherichia coli
Keywords: ناک اوت; Chaperone; Knock out; Microarray; Metabolism
Immunomodulatory properties of oat and barley β-glucan populations on bone marrow derived dendritic cells
Keywords: ناک اوت; Dendritic cells; Homogenisation; Immunomodulation; Particulate; Solubility; AF4; asymmetric flow field flow fractionation; BMDC; bone marrow derived dendritic cell; DC; dendritic cell; DP; degree of polymerisation; fd; freeze-dried; hs; heated-soluble; HP
Donepezil, an acetylcholine esterase inhibitor, and ABT-239, a histamine H3 receptor antagonist/inverse agonist, require the integrity of brain histamine system to exert biochemical and procognitive effects in the mouse
Keywords: ناک اوت; HDC-KO mice; a-fluoromethylhistidine; Object recognition test; Memory; Acetylcholine; GSK-3β; a-FMHis; alpha-fluromethylhistidine; H3R; histamine H3 receptor; HDC; histidine decarboxylase; ORT; object recognition test; T1; training session; T2; test sess
Targeted mutagenesis of an odorant receptor co-receptor using TALEN in Ostrinia furnacalis
Keywords: ناک اوت; Genome editing; Knock out; Lepidoptera; Mutant; Non-model insect;
Novel role for galectin-1 in T-cells under physiological and pathological conditions
Keywords: ناک اوت; Gal-1; galectin-1; rGal-1; recombinant Gal-1; inGal-1/exGal-1; intracellular/extracellular Gal-1; SLE; systemic lupus erythematosus; KO; knock out; BMMSC; bone marrow mesenchymal stem cell; Intracellular galectin-1; Activated T-cells; Systemic lupus eryth
Increased sensitivity to kindling in mice lacking TSP1
Keywords: ناک اوت; CNS; central nervous system; EGF; epidermal growth factor; IP; intraperitoneal injection; KO; knock out; PTZ; pentylenetetrazole; PNS; peripheral nervous system; qPCR; quantitative polymerase chain reaction; TSP; thrombospondin; TGF-β; transforming growt
Differential effects of IL-15 on the generation, maintenance and cytotoxic potential of adaptive cellular responses induced by DNA vaccination
Keywords: ناک اوت; IL-15; Knock out; DNA vaccine; Immune response; Cytotoxic potential; HIV; GzmB; granzyme B; KO; knockout; Tcm; central memory T cells; Tem; effector memory T cells; WT; wild type;
PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation
Keywords: ناک اوت; PAK1; p-21 activated kinase 1; PPARγ; peroxisome proliferator associated receptor gamma; IBD; inflammatory bowel disease; NF-κB; nuclear factor-kappa B; CRC; colorectal cancer; UC; ulcerative colitis; CD; Crohn's disease; CAC; colitis-associated cancer;
Left ventricular diastolic dysfunction in Nrf2 knock out mice is associated with cardiac hypertrophy, decreased expression of SERCA2a, and preserved endothelial function
Keywords: ناک اوت; BP; blood pressure; CO; cardiac output; DP; developed pressure; DT; deceleration time; FMD; flow-mediated dilation; GC; guanylyl cyclase; IVRT; isovolumic relaxation time; KO; knock out; LV; left ventricular; MVET; mitral valve ejection time; Nrf2; nuclea
Editing of the heavy chain gene of Bombyx mori using transcription activator like effector nucleases
Keywords: ناک اوت; Knock out; H-chain; Recombinant protein; Sericin cocoon; TALENs; Silkworm;
Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model
Keywords: ناک اوت; Siglec; sialic acid binding immunoglobulin like lectin; OVA; ovalbumin; WT; wild type; KO; knock out; KI; knock in; ITIM; immunoreceptor tyrosine based inhibitory motifs; Siglec-F; Siglec-8; Eosinophil; Allergic airway inflammation;
Plasmodium berghei glycine cleavage system T-protein is non-essential for parasite survival in vertebrate and invertebrate hosts
Keywords: ناک اوت; Glycine cleavage system; T-protein; Plasmodium falciparum; Plasmodium berghei; Mitochondrion; Knock out;
Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor function
Keywords: ناک اوت; 5-HT; serotonin; Akt; protein kinase B; DOI; (±)-2,5-dimethoxy-4-iodoamphetamine hydrochloride; ERK1/2; extracellular signal-regulated protein kinases 1 and 2; GSK-3β; glycogen synthase kinase-3beta; KO; knock out; 8-OH-DPAT; [8-hydroxy-2-(di-n-propylam
Invadosomes in their natural habitat
Keywords: ناک اوت; 2D; two-dimensional; 3D; three-dimensional; cAMP; 3, 5-cyclic adenosine monophosphate; Ab; antibody; AC; anchor cell; Arp2/3; complex containing actin regulators 2 and 3; BM; basement membrane; CAM; chicken chorioallantoic membrane; Cdc42; Cell division c
The role of the neuropeptide S system in addiction: Focus on its interaction with the CRF and hypocretin/orexin neurotransmission
Keywords: ناک اوت; NPS; neuropeptide S; NPSR; neuropeptide S receptor; CRF; corticotrophin releasing factor; Hcrt-1/Ox-A; hypocretin-1/orexin-A; GPR154; G protein coupled receptor 154; ppNPS; prepropeptide NPS; Lys-Arg; lysine-arginine; mRNA; messenger RNA; LC; locus co
Expression of CaV3.2 T-type Ca2+ channels in a subpopulation of retinal type-3 cone bipolar cells
Keywords: ناک اوت; CBC; cone bipolar cell; EGTA; ethylene glycol tetraacetic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; HCN4; hyperpolarization-activated and cyclic nucleotide-gated channel 4; HEK; human embryonic kidney; IPL; inner plexiform layer; KO