Neonatal administration of phencyclidine decreases the number of putative inhibitory interneurons and increases neural excitability to auditory paired clicks in the hippocampal CA3 region of freely moving adult mice

► Effects of administration of phencyclidine during neonatal period were examined. ► Unit activities were recorded from the hippocampal CA3 in freely moving mice. ► The mice had undergone administration of phencyclidine during the neonatal period. ► Treatment decreased the number of fast-spiking neurons. ► Treatment increased the excitability of regular-spiking neurons to paired-clicks.