Activity-dependent neurotrophic factor-derived peptide prevents alcohol-induced apoptosis, in part, through Bcl2 and c-Jun N-terminal kinase signaling pathways in fetal brain of C57BL/6 mouse

▶We investigated ADNF-9 neuroprotection in fetal alcohol exposure model. ▶ADNF-9 treatment prevented alcohol-induced reductions in fetal brain weight. ▶ADNF-9 prevented an alcohol-induced increase in cell death in fetal brain regions. ▶Neuroprotective effect of ADNF-9 is mediated through Bcl2 and JNK pathways. ▶ADNF-9 neuroprotection provides potential therapeutics in fetal alcohol exposure.