کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6276754 | 1295742 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Changes in and dorsal to the rat suprachiasmatic nucleus during early pregnancy
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کلمات کلیدی
ovariectomized0.01 M phosphate-buffered salineACTHTriton-X 100ER-βdorsomedialREMSNREMSSCNNHSGRPAVPOVXVIPLSDABCFOSDABPBSNGSSPZPer2 - per2ventrolateral - ventrolateralImmunoreactivity - ایمنی فعالthird ventricle - بطن سومconstant darkness - تاریکی دائمیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceReproduction - تولید مثل یا زادآوریlight/dark - تیره روشن یا کمرنگ و پررنگtyrosine hydroxylase - تیروزین هیدروکسیلازleast significant difference - حداقل تفاوت قابل توجهیNon-rapid eye movement sleep - حرکت سریع چشم بدون خوابrapid eye movement sleep - حرکت چشم سریع خوابper - در هرCircadian Time - دوران جوانیPeriod - دوره زمانیdiaminobenzidine - دیامینو بنزیدینCircadian rhythm - ریتم شبانه روزیZeitgeber time - زمان تایمرnormal horse serum - سرم طبیعی اسبnormal goat serum - سرم طبیعی بزavidin-biotin peroxidase complex - مجتمع آویدین-بیوتین پراکسیدازSubparaventricular zone - منطقه فرعی دریاییSuprachiasmatic nucleus - هستههای سوپراکیاسماتیکarginine vasopressin - وازوپرسین آرژینینgastrin-releasing peptide - پپتید آزاد کننده گاسترینvasoactive intestinal peptide - پپتید روده روده ایoptic chiasm - چیماس اپتیکی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Circadian rhythms in behavior and physiology change as female mammals transition from one reproductive state to another. The mechanisms responsible for this plasticity are poorly understood. The suprachiasmatic nucleus (SCN) of the hypothalamus contains the primary circadian pacemaker in mammals, and a large portion of its efferent projections terminate in the ventral subparaventricular zone (vSPZ), which also plays important roles in rhythm regulation. To determine whether these regions might mediate changes in overt rhythms during early pregnancy, we first compared rhythms in Fos and Per2 protein expression in the SCN and vSPZ of diestrous and early pregnant rats maintained in a 12:12-h light/dark (LD) cycle. No differences in the Fos rhythm were seen in the SCN core, but in the SCN shell, elevated Fos expression was maintained throughout the light phase in pregnant, but not diestrous, rats. In the vSPZ, the Fos rhythm was bimodal in diestrous rats, but this rhythm was lost in pregnant rats. Peak Per2 expression was phase-advanced by 4 h in the SCN of pregnant rats, and some differences in Per2 expression were found in the vSPZ as well. To determine whether differences in Fos expression were due to altered responsivity to light, we next characterized light-induced Fos expression in the SCN and vSPZ of pregnant and diestrous rats in the mid-subjective day and night. We found that the SCN core of the two groups responded in the same way at each time of day, whereas the rhythm of Fos responsivity in the SCN shell and vSPZ differed between diestrous and pregnant rats. These results indicate that the SCN and vSPZ are functionally re-organized during early pregnancy, particularly in how they respond to the photic environment. These changes may contribute to changes in overt behavioral and physiological rhythms that occur at this time.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 171, Issue 2, 1 December 2010, Pages 513-523
Journal: Neuroscience - Volume 171, Issue 2, 1 December 2010, Pages 513-523
نویسندگان
J.A. Schrader, A.A. Nunez, L. Smale,