کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6276858 | 1295745 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Haloperidol and clozapine decrease S100B release from glial cells
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کلمات کلیدی
PBSDMEMSGDRPMIDAPIS100BDulbecco's modified Eagle's medium - Medal of Eagle اصلاح شده Dulbeccov/v - V / VAstrocytes - آستروسیتEDTA - اتیلن دی آمین تترا استیک اسید Ethylenediaminetetraacetic acid - اتیلینیدامین تتراستیک اسیدSchizophrenia - اسکیزوفرنی یا شیزوفرنیvolume per volume - حجم در هر جلدPhosphate buffered saline - فسفات بافر شورRoswell Park Memorial Institute medium - موسسه خاطرات Roswell Park mediumHaloperidol - هالوپریدولPropidium iodide - پروتئین یدیدclozapine - کلوزاپین Muscarinic acetylcholine receptors - گیرنده های استیل کولین MuscarinicSerotonin receptors - گیرنده های سروتونینoligodendrocytes - یاخته کم شاخه، الیگودندروسیت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Haloperidol and clozapine decrease S100B release from glial cells Haloperidol and clozapine decrease S100B release from glial cells](/preview/png/6276858.png)
چکیده انگلیسی
Recent meta-analyses showed consistently elevated levels of S100B in serum and cerebrospinal fluid of schizophrenic patients. This finding has been attributed to glial pathology because S100B is produced by astrocytes and oligodendrocytes. However, S100B may be likewise associated with schizophrenia-related disturbances in glial cell as well as adipocyte energy supply and glucose metabolism. The influence of antipsychotic drugs on S100B levels remains unclear, and some studies have suggested that treatment with these drugs may actually contribute to the elevated S100B levels observed in schizophrenic patients. In this study, we explored the effects of the typical antipsychotic haloperidol and the atypical prototype drug clozapine on the release of S100B by astrocytic C6 cells and oligodendrocytic OLN-93 cells. Because of the association between schizophrenia and disturbances in energy metabolism, we assessed the effects of these drugs under basal condition (BC) compared to serum and glucose deprivation (SGD). We found that treatment of C6 and OLN-93 cells with haloperidol and clozapine reduced the release of S100B from C6 and OLN-93 cells under BC and SGD in vitro at a tissue concentration corresponding to the assumed therapeutic dose range of these drugs. These data suggest that elevated levels of S100B in bodily fluids of schizophrenic patients are normalized rather than increased by the effects of antipsychotic drugs on glial cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 167, Issue 4, 2 June 2010, Pages 1025-1031
Journal: Neuroscience - Volume 167, Issue 4, 2 June 2010, Pages 1025-1031
نویسندگان
J. Steiner, M.L. Schroeter, K. Schiltz, H.G. Bernstein, U.J. Müller, C. Richter-Landsberg, W.E. Müller, M. Walter, T. Gos, B. Bogerts, G. Keilhoff,