کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6276924 | 1295746 | 2010 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functional role of Calcium-stimulated adenylyl cyclase 8 in adaptations to psychological stressors in the mouse: implications for mood disorders
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کلمات کلیدی
ACTHpolypeptide YYPYYGIPRIADKOFSTcAMP - cAMPCyclic adenosine monophosphate - آدنوزین مونوفسفات Cyclicadenylyl cyclase - آدنیلات سیکلاز، آدنیلیل سیکلازradio immuno assay - آزمایش ایمنی رادیوییforced swim test - آزمون شناور اجباریKnock out mice - از دست دادن موش هاSocial stress - استرس اجتماعیlong term depression - افسردگی بلند مدتHyperactivity - بیش فعالیlong term potentiation - تقویت طولانی مدتLTP - تقویت طولانی مدت یا LTP standard error of mean - خطای استاندارد میانگینdouble knock out - دو بار ضربه بزنیدMania - شیدایی یا مانیاLeptin - لپتین Metabolism - متابولیسم LTD - محدودSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیHPA - میلی بار یا هکتوپاسکالknock-out - ناک اوتwild type - نوع وحشیadrenocorticotropic hormone - هورمون adrenocorticotropichypothalamo–pituitary–adrenal - هیپوتالامو-هیپوفیز-آدرنالpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازPancreatic polypeptide - پالپپتید پانکراس
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
The Ca2+/calmodulin stimulated adenylyl cylcase 8 (AC8) is a pure Ca2+ sensor, catalyzing the conversion of ATP to cAMP, with a critical role in neuronal plasticity. A role for AC8 in modulating complex behavioral outcomes has been demonstrated in AC8 knock out (KO) mouse models in which anxiety-like responses were differentially modulated following repeated stress experiences, suggesting an involvement of AC8 in stress adaptation and mood disorders. To further investigate the role of this enzyme in phenotypes relevant for psychiatric conditions, AC8 KO mice were assessed for baseline behavioral and hormonal parameters, responses to repeated restraint stress experience, and long-term effects of chronic social defeat stress. The lack of AC8 conferred a hyperactive-phenotype both in home-cage behaviors and the forced swim test response as well as lower leptin plasma levels and adrenal hypertrophy. AC8 KO mice showed baseline “anxiety” levels similar to wild type littermates in a variety of procedures, but displayed decreased anxiety-like responses following repeated restraint stress. This increased stress resilience was not seen during the chronic social defeat procedure. AC8 KO did not differ from wild type mice in response to social stress; similar alterations in body weight, food intake and increased social avoidance were found in all defeated subjects. Altogether these results support a complex role of cAMP signaling pathways confirming the involvement of AC8 in the modulation of stress responses. Furthermore, the hyperactivity and the increased risk taking behavior observed in AC8 KO mice could be related to a manic-like behavioral phenotype that warrants further investigation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 170, Issue 2, 13 October 2010, Pages 429-440
Journal: Neuroscience - Volume 170, Issue 2, 13 October 2010, Pages 429-440
نویسندگان
M. Razzoli, M. Andreoli, G. Maraia, C. Di Francesco, R. Arban,