کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277253 | 1295749 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparison of metabolic and neuropathy profiles of rats with streptozotocin-induced overt and moderate insulinopenia
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کلمات کلیدی
VMRPPTVisceromotor reflexGTTIENF8-OHdGMNCVCRDFTTHbA1cDPNSTZ8-hydroxydeoxyguanosine - 8 هیدروکسی دیواکسی گوآزینAllodynia - آلودینیا colorectal distension - اختلال کولورکتالstreptozotocin - استرپتوزوتوسینelectromyographic - الکترومیوگرافیEMG - الکترومیوگرافیIntraepidermal nerve fibers - الیاف عصبی درون اپیدرمالinsulin - انسولینDiabetes - بیماری قندglucose tolerance test - تست تحمل گلوکزmotor nerve conduction velocity - سرعت هدایت عصب موتورperipheral nervous system - سیستم عصبی پیرامونیpressure pain threshold - فشار آستانه دردFasting plasma glucose - قند خون ناشتاHyperglycemia - هایپرگلایسمیHemoglobin A1c - هموگلوبین A1cHyperalgesia - پردردی یا هایپرآلژزیPre-diabetes - پیش دیابتPNS - کارمندان دولت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Comparison of metabolic and neuropathy profiles of rats with streptozotocin-induced overt and moderate insulinopenia Comparison of metabolic and neuropathy profiles of rats with streptozotocin-induced overt and moderate insulinopenia](/preview/png/6277253.png)
چکیده انگلیسی
To assess the relative roles of insulinopenia, hyperglycemia and dyslipidemia in pathogenesis of diabetic neuropathy, we compared plasma insulin, glucose and lipid metabolism and peripheral nerve function in rats with streptozotocin (STZ)-induced overt and moderate insulinopenia (hyperglycemic, STZ-HG; random glucose>11 mM and normoglycemic, STZ-NG rats). While being slightly insulinopenic, STZ-NG rats are metabolically not different from control, naive animals, by having normal glucose tolerance and normal levels of plasma glucose, glycated HbA1c, cholesterol and triglycerides. Two weeks following injection of STZ, STZ-HG but not STZ-NG rats had suppressed motor nerve conduction velocity, F-wave prevalence, withdrawal responses to heat and von Frey filament stimuli. In apparent correlation with plasma insulin level, both STZ-HG and -NG rats manifested exaggerated responses in paw pressure and colorectal distension tests. These data suggest that insulinopenia may play a leading role in the diabetic impairment of deep muscle and visceral afferent pathways while hyperglycemia/dyslipidemia may represent a key requirement for the onset and progression of electrophysiological nerve impairment and loss of superficial heat and tactile perception. STZ-NG rats offer a convenient model for the investigation of the short-term effects of insulinopenia on peripheral nerve function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 170, Issue 1, 29 September 2010, Pages 337-347
Journal: Neuroscience - Volume 170, Issue 1, 29 September 2010, Pages 337-347
نویسندگان
D. Romanovsky, J. Wang, E.D. Al-Chaer, J.R. Stimers, M. Dobretsov,