کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278078 | 1295793 | 2009 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activity-dependent plasticity of developing climbing fiber-Purkinje cell synapses
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کلمات کلیدی
GluRδ2TrkBmGluR1EPSC - EPSCoRlong-term depression - افسردگی طولانی مدتlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP Tyrosine kinase B - تیروزین کیناز بexcitatory postsynaptic current - جریان پستیینپتیک تحریک کنندهsynapse elimination - حذف سیناپسDevelopment - رشدembryonic day - روز جنینیpostnatal day - روز پس از زایمانparallel fiber - فیبر موازیLTD - محدودCerebellum - مخچهMetabotropic glutamate receptor type 1 - نوع 1 گیرنده گلوتامات متابوتروپیکSynaptic plasticity - پلاستیسیته سیناپسی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Elimination of redundant synapses and strengthening of the surviving ones are crucial steps in the development of the nervous system. Both processes can be readily followed at the climbing fiber to Purkinje cell synapse in the cerebellum. Shortly after birth, around five equally strong climbing fiber synapses are established. Subsequently, one of these five synaptic connections starts to grow in size and synaptic strength, while the others degenerate and eventually disappear. Both the elimination of the redundant climbing fiber synapses and the strengthening of the surviving one depend on a combination of a genetically coded blueprint and synaptic activity. Recently, it has been shown that synaptic activity affects the synaptic strength of developing climbing fibers. Remarkably, the same pattern of paired activity of the presynaptic climbing fiber and the postsynaptic Purkinje cell resulted in strengthening of already “large” climbing fibers and weakening of already “weak” climbing fibers. In this review, we will integrate the current knowledge of synaptic plasticity of climbing fibers with that of other processes affecting climbing fiber development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 162, Issue 3, 1 September 2009, Pages 612-623
Journal: Neuroscience - Volume 162, Issue 3, 1 September 2009, Pages 612-623
نویسندگان
L.W.J. Bosman, A. Konnerth,