کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278299 | 1295814 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Amygdala-dependent and amygdala-independent pathways for contextual fear conditioning
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کلمات کلیدی
vPAGBLAbasolateral amygdaloid complexVentral periaqueductal grayaCSFHPCCeA - CEAAmygdala - آمیگدال، بادامهAnxiety - اضطرابFreezing - انجمادFear conditioning - تهدید ترسMemory - حافظهartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیmusc - مشکmuscimol - موسیمول central nucleus of the amygdala - هسته مرکزی آمیگدالHippocampus - هیپوکامپ Learning - یادگیری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The basolateral amygdala (BLA), consisting of the lateral and basal nuclei, is considered to be essential for fear learning. Using a temporary inactivation technique, we found that rats could acquire a context-specific long-term fear memory without the BLA but only if intensive overtraining was used. BLA-inactivated rats' learning curves were characterized by slow learning that eventually achieved the same asymptotic performance as rats with the BLA functional. BLA inactivation abolished expression of overtrained fear when rats were overtrained with a functional BLA. However, BLA-inactivation had no effect on the expression of fear in rats that learned while the BLA was inactivated. These data suggest that there are primary and alternate pathways capable of mediating fear. Normally, learning is dominated by the more efficient primary pathway, which prevents learning in the alternate pathway. However, alternate pathways compensate when the dominant pathway is compromised.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 147, Issue 4, 29 July 2007, Pages 919-927
Journal: Neuroscience - Volume 147, Issue 4, 29 July 2007, Pages 919-927
نویسندگان
R. Ponnusamy, A.M. Poulos, M.S. Fanselow,