کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278565 | 1295823 | 2007 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chronic use of marijuana decreases cannabinoid receptor binding and mRNA expression in the human brain
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کلمات کلیدی
Substantia nigra pars reticulatatetrahydrocannabinolcRNABmaxGPiTHCVTAS.E.M.GPESSCSR141716AcDNA - cDNAComplementary DNA - DNA تکمیلیcomplementary RNA - RNA مکملSNpr - SNPRDissociation constant - حد تفکیکstandard error of the mean - خطای استاندارد میانگینPsychostimulants - روانشناسیCannabis sativa - ساندویچ سیب زمینیPostmortem human brain - مغز انسان پس از قاعدگیcannabinoid receptors - گیرنده های کانابینوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Chronic exposure to Cannabis sativa (marijuana) produced a significant down-regulation of cannabinoid receptor in the postmortem human brain. The significant decrease in maximal binding capacity was not accompanied by changes in the affinity constant. [3H]SR141716A binding was reduced in the caudate nucleus, putamen and in the accumbens nucleus. A significant decrease of binding sites was seen in the globus pallidus. Also in the ventral tegmental area and substantia nigra pars reticulata quantitative analysis of the density of receptors shows a significant reduction in [3H]SR141716A binding. In Cannabis sativa user brains, compared with normal brains [3H]SR141716A binding was reduced only in the hippocampus. The density of cannabinoid receptor 1 mRNA-positive neurons was significantly lower in Cannabis sativa users than in control brains for the caudate nucleus, putamen, accumbens nucleus and hippocampal region (CA1-CA4, areas of Ammon's horn). No hybridization was seen in the mesencephalon and globus pallidus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 145, Issue 1, 2 March 2007, Pages 323-334
Journal: Neuroscience - Volume 145, Issue 1, 2 March 2007, Pages 323-334
نویسندگان
J. Villares,