Keywords: Bmax; maximum binding capacity; CNV; choroidal neovascularization; DCT; dopachrome tautomerase; DHI; 5,6-dihydroxyindole; DHICA; 5,6-dihydroxyindole-2-carboxylic acid; DOPA; dihydroxyphenylalanine; HPLC; high performance liquid chromatography; IQ; 5,6-ind
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Keywords: Dopamine; Serotonin; Obesity; Neuroimaging; Humans; 5-HT1A,B; serotonin 1A and 1B receptor; 5-HT2A; serotonin 2A receptor; 5-HT2C; serotonin 2C receptor; 5-HT4; serotonin 4 receptor; Bmax; receptor or transporter availability; BMI; body mass index; BP; bi
Keywords: Bmax; total density of receptors/targets in a sample tissue; L; free ligand concentration; In; input of ligand; Cl(L); non-specific unbound ligand clearance; Ctot; total concentration of ligand (free and ligand bound non-specifically to e.g., plasma prote
Keywords: β-adrenergic receptor; phospholamban; pathological gene program; α-MyHC; α-Myosin heavy chain; β-AR; β-Adrenergic receptor; β1-AR; β1-Adrenergic receptor; β2-AR; β2-Adrenergic receptor; Bmax; Total β-adrenergic receptor expression; GRK2; G prote
Keywords: 5-HT; 5-Hydroxytryptamine, serotonin; ACh; Acetylcholine; AChE; Acetylcholine esterase; AMPA; (RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; BAPTA; 1,2-Bis(o-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid; Bmax; Maximum binding capacity;
Keywords: BA; bile acid; Bmax; maximum specific ligand binding; CH; casein hydrolysate; CPc; crude casein plastein; CPi; isolated casein plastein; DCA; deoxycholic acid; HHR; hydrophobic-to-hydrophilic amino acid ratio; Ho; calculated hydrophobicity; Kd; ligand dis
Keywords: AIBN; 2,2â²-azo-bis-iso-butyronitrile; Bmax; maximum binding sites; EGDMA; ethylene glycol dimethacrylate; KD; dissociation constant; MAA; methacrylic acid; MISPE; molecularly imprinted solid-phase extraction; NIP; non-imprinted polymer; ACN; acetonitril
Keywords: Androgens; Androgenic receptor; Hexokinase; Ionising radiation; Testosterone-binding globulin; A; androgen(s); aa; amino acids; ABP; androgen-binding protein of rat i.e. rTeBG; AC; adenylate cyclase; AR; androgen receptor; ARC; androgen receptor complex;
Pb2Â + modulates ryanodine receptors from the endoplasmic reticulum in rat brain
Keywords: Bmax; the maximal number of ryanodine-binding site; Ca2Â +; Â calcium ion; cADPR; cyclic ADP-ribose; ER; endoplasmic reticulum; GSH; reduced glutathione; Kd; the equilibrium binding constant; Mg2Â +; Â magnesium ion; Pb2Â +; Â lead ion; PKA; cAMP-dependen
Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in non-anesthetized rat
Keywords: Bmax; concentration of total D2 binding site in striatum; ECF; extracellular fluid; IV; intravenous; Kd; drug affinity to the receptor; koff; drug dissociation rate from the receptor; kon; drug association rate to the receptor; PET; positron emission tomo
Synthesis and preclinical evaluation of [11C]MA-PB-1 for in vivo imaging of brain monoacylglycerol lipase (MAGL)
Keywords: MAGL; [11C]MA-PB-1; MJN110; Biodistribution; PET imaging; AA; arachidonic acid; AEA; N-arachidonoyl ethanolamine; 2-AG; 2-arachidonoyl glycerol; BBB; blood brain barrier; Bmax; enzyme expression; BBr3; boron tribromide; CB1; cannabinoid 1 receptors; CDCl3
Neuroscience Forefront ReviewNeuroimaging in animal models of epilepsy
Keywords: 1H-MRS; proton MRS; 2-DG; 2-deoxy-D-glucose; 3D; three-dimensional; ADC; apparent diffusion coefficient; ADCav; averaged ADC; ASL; arterial spin labeling; BBB; bloodbrain barrier; Bmax; receptor density; BOLD; blood oxygenation level-dependent; CA; cornu
Radioligand binding assay for accurate determination of nuclear retinoid X receptors: A case of triorganotin endocrine disrupting ligands
Keywords: ATRA; all-trans retinoic acid; Bmax; maximal binding capacity (pmol/mg); DNA; deoxyribonucleic acid; DR; direct repeat; DTT; 1,4-dithiothreitol; FXR; farnesoid X receptor; Ka; affinity (l/mol); LBD; ligand-binding domain; LXR; liver X receptor; PMSF; phen
Synthesis and binding characteristics of [3H]neuromedin N, a NTS2 receptor ligand
Keywords: BH; Bolton-Hunter; Bmax; maximal number of the binding sites; BSA; bovine serum albumin; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; EC50; half maximal effective concentration; Emax; maximal stimulation (Efficacy); GDP; guanosine 5â²-
CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift
Keywords: AIP; autocamtide-2 related inhibitory peptide; Bmax; binding maximum; CaM; calmodulin; CaMKII; calcium/calmodulin-dependent protein kinase II; CaSpF; calcium spark frequency; CPVT; catecholaminergic polymorphic ventricular tachycardia; DAN; dantrolene; F;
SW43-DOX ± loading onto drug-eluting bead, a potential new targeted drug delivery platform for systemic and locoregional cancer treatment - An in vitro evaluation
Keywords: Sigma-2 receptor; Doxorubicin; Targeted cancer therapy; Drug-eluting bead (DEB); ATP; Adenosine Triphosphate; Bmax; Maximal Specific Cell Surface Binding Capacity; BSA; Bovine Serum Albumin; DAPI; 4',6-diamidino-2-phenylindole, dilactate; DMSO; Dimethyl S
Streptococcal serum opacity factor promotes cholesterol ester metabolism and bile acid secretion in vitro and in vivo
Keywords: Bmax; maximum uptake; C; cholesterol; CE; cholesteryl ester; CERM; cholesteryl ester rich microemulsion; FBS; fetal bovine serum; FC; free cholesterol; GC-MS; gas chromatography-mass spectrometry; HDL; high density lipoprotein; HPTLC; high performance
Radiosynthesis and in vitro validation of 3H-NS14492 as a novel high affinity alpha7 nicotinic receptor radioligand
Keywords: Bmax; maximum density; 125I-BTX; 125I-α-bungarotoxin; Kd; dissociation constant; Ki; inhibition constant; NSB; non-specific binding; OD; optical density; PAM; positive allosteric modulator; SB; specific binding; TB; total binding; TE; tissue equivalent;
A tyrosine-containing analog of mu-conotoxin GIIIA as ligand in the receptor binding assay for paralytic shellfish poisons
Keywords: Mu-conotoxin GIIIA; Paralytic shellfish poisoning; Receptor binding assay; Saxitoxin; μ1; skeletal muscle Na channel subtype; μ-CTX; μ-conotoxin; AOAC; Association of Official Analytical Communities, current official name is AOAC International; Bmax; m
Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity
Keywords: Ï; time constant; Ïwash-in; wash-in time constant; Ïwash-out; wash-out time constant; AIP; autocamtide-2 related inhibitory peptide; Bmax; binding maximum; CaM; calmodulin; CaSpF; calcium spark frequency; DAN; dantrolene; F; fluorescent; FDHM; full dur
Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor
Keywords: Boc; butoxycarbonyl; Bmax; receptor density; DMEM; Dulbecco's Modified Eagle's Medium; DMF; N,N-dimethylformamide; FBS; fetal bovine serum; GPCR; G protein-coupled receptor; HBTU; 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphat
Selective and simultaneous determination of trace bisphenol A and tebuconazole in vegetable and juice samples by membrane-based molecularly imprinted solid-phase extraction and HPLC
Keywords: Bisphenol A (PubChem CID: 6623); Bisphenol C (PubChem CID: 6620); Bisphenol Z (PubChem CID: 232446); Estradial (PubChem CID: 5757); Hydroquinone (PubChem CID: 785); Tebuconazole (PubChem CID: 86102); Hexaconazole (PubChem CID: 66461); Flutriafol (PubChem
Investigating the interactions of the 18Â kDa translocator protein and its ligand PK11195 in planar lipid bilayers
Keywords: ANTA; nitrilotriacetic acid group with a terminal amino group; Bmax; maximal number of receptor binding sites; CMAu; gold contrast matched water; CMSi; silicon contrast matched water; CM4; scattering length density 4 contrast matched water; DDM; n-dodecyl
Involvement of apoptosis and autophagy in the death of RPMI 8226 multiple myeloma cells by two enantiomeric sigma receptor ligands
Keywords: AI; apoptosis inhibitor; Bmax; maximal ligand binding sites; BODIPY 665/676 C11; 4-difluoro-3,5-bis(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-indacene; DCFDA; 2â²,7â²-dichlorofluorescein diacetate; DAPI; 4,6-diamino-2-phenylindole; DMSO; dimethylsul
Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6
Keywords: AEM; adenovirus expression medium; ApoB, ApoCI, ApoE; apolipoprotein B, CI, E; BSA; bovine serum albumin; HCVcc; cell culture produced hepatitis C virus; FBS; fetal bovine serum; FFU; Focus Forming Units; HCV; hepatitis C virus; HRP; horseradish peroxidas
5-HT1A sex based differences in Bmax, in vivo KD, and BPND in the nonhuman primate
Keywords: 5-HT; Serotonin; 5-HT1A; Bmax; KD; Sex differences;
Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD
Keywords: PTSD; posttraumatic stress disorder; GR; glucocorticoid receptor; PBMCs; peripheral blood mononuclear cells; Bmax; number of glucocorticoid binding sites; KD; equilibrium dissociation constant; HPA axis; hypothalamic-pituitary-adrenocortical axis; CAPS-DX
The three α1-adrenoceptor subtypes show different spatio-temporal mechanisms of internalization and ERK1/2 phosphorylation
Keywords: α1-AR; α1 adrenoceptor; β2-AR; β2 adrenoceptor; AT1AR; angiotensin receptor type 1A; Bmax; maximum number of binding sites; BSA; bovine serum albumin; ConA; concanavalin A; DMSO; dimethyl sulfoxide; EGFR; epidermal growth factor receptor; GAPDH; glyce
Cholinergic and GABAergic receptor functional deficit in the hippocampus of insulin-induced hypoglycemic and streptozotocin-induced diabetic rats
Keywords: hypoglycemia; diabetes; hippocampus; cholinergic receptor; GABA; AchE; acetylcholine esterase; Bmax; maximal binding; ChAT; choline acetyltransferase; C+IIH; insulin-induced hypoglycemia in control rats; CT; threshold cycle; DAMP; 4-deoxy acetyl methyl pi
The third intracellular loop of D1 and D5 dopaminergic receptors dictates their subtype-specific PKC-induced sensitization and desensitization in a receptor conformation-dependent manner
Keywords: AC; adenylyl cyclase; Bmax; maximal binding capacity; BSA; bovine serum albumin; β2-AR; β2-adrenergic receptor; CA; [3H]-cAMP formed; CT; cytoplasmic tail; DA; dopamine; DMSO; dimethyl sulfoxide; EL3; third extracellular loop; EC50; effective concentrat
Uniform assessment and ranking of opioid Mu receptor binding constants for selected opioid drugs
Keywords: MOR; Mu opioid receptor; DOR; delta opioid receptor; KOR; kappa opioid receptor; DAMGO; (d-Ala2, N-MePhe4, Gly-ol)-enkephalin; GPCR; G-protein coupled receptors; FDA; Food and Drug Administration; Ki; equilibrium dissociation constant for the test compoun
Structural and functional roles of small group-conserved amino acids present on helix-H7 in the β2-adrenergic receptor
Keywords: β2-AR; β2-adrenergic receptor; Bmax; Binding maximum of the ligand for the receptor; COS-1; Monkey kidney cells; GPCRs; G protein-coupled receptors; HEK293; human embryonic kidney cells; [3H] DHA; tritium labeled dihydroalprenolol; Kd; equilibrium disso
A comprehensive study on the putative δ-opioid receptor (sub)types using the highly selective δ-antagonist, Tyr-Tic-(2S,3R)-β-MePhe-Phe-OH
Keywords: Bmax; receptor density; BNTX; 7-benzylidenenaltrexone; DADLE; [d-Ala2,d-Leu5]enkephalin; deltorphin II; Tyr-d-Ala-Phe-Glu-Val-Val-Gly-NH2; DOR-1; δ-opioid receptor; DOR-KO; δ-opioid receptor knock-out; DPDPE; Tyr-c[d-Pen-Gly-Phe-d-Pen]-OH; DSLET; Tyr-d-
Continuous light and melatonin: Daily and seasonal variations of brain binding sites and plasma concentration during the first reproductive cycle of sea bass
Keywords: Photoperiod manipulation; Dicentrarchus labrax; Reproduction; Variations; Melatonin receptors; Kd; Bmax;
Cortical M1 receptor concentration increases without a concomitant change in function in Alzheimer's disease
Keywords: Bmax; GPCR; Functional activity; MCI; Muscarinic receptor
Pro-inflammatory responses in human monocytes are β1-adrenergic receptor subtype dependent
Keywords: ARs; adrenergic receptors; Bmax; maximal specific binding of radioligand; CGP 20712A; [1-(2-((3-carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazoylyl)phenoxy)-2-propanol methanesulfonate, 2-hydroxy-5-(2-(hydroxy-3-(4-((1-m
Increased glutamate receptor gene expression in the cerebral cortex of insulin induced hypoglycemic and streptozotocin-induced diabetic rats
Keywords: hypoglycemia; glutamate excitotoxicity; cerebral cortex; NMDA2B; mGluR5; ANOVA; analysis of variance; Bmax; maximal binding; CT; threshold cycle; IIH; insulin-induced hypoglycemia; Kd; equilibrium dissociation constant; mGluR; metabotropic glutamate recep
Chronic use of marijuana decreases cannabinoid receptor binding and mRNA expression in the human brain
Keywords: Cannabis sativa; CB1 receptor binding; chronic drug exposure; postmortem human brain; mRNA CB1 expression; psychostimulants; Bmax; maximal capacity; CA1, CA2, CA3, CA4; areas of Ammon's horn; CB1, CB2; cannabinoid receptors; cDNA; complementary DNA; cRN
The platelet maximum number of A2A-receptor binding sites (Bmax) linearly correlates with age at onset and CAG repeat expansion in Huntington's disease patients with predominant chorea
Keywords: Age at onset; Onset chorea; A2A-receptor dysfunction; Bmax; CAG repeat expansion; Platelets;
Low density and high affinity of platelet [3H]paroxetine binding in women with bulimia nervosa
Keywords: Bulimia nervosa; [3H]paroxetine binding; Serotonin transporter; Platelets; Bmax; Kd; Women
Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress
Keywords: stress; adenosine; A1 receptor; A2A receptor; hippocampus; nerve terminals; ANOVA; analysis of variance; Bmax; maximal number of binding sites; DPCPX; 1,3-dipropyl-8-cyclopentylxanthine; HPA; hypothalamic-pituitary-adrenal; KD; dissociation constant;
Natural terpenes: Self-assembly and membrane partitioning
Keywords: A; absorbance; ANOVA; analysis of variance; Bmax; maximal binding; BTB; bromothymol blue; CAM; camphor; CIN; 1,8-cineole; CMC; critical micellar concentration; D; dielectric constant; ÎÏ0; maximal ÎÏ determined by extrapolation to zero Ïi; dpPC; dipa
Pharmacological characterization and autoradiographic distribution of α2-adrenoceptor antagonist [3H]RX 821002 binding sites in the chicken brain
Keywords: chicken brain; α2-adrenoceptor; RX 821002; membrane homogenate binding; autoradiography; competition; ARC 239; 2-(2-4-(O-methoxyphenyl)-piperazin-1-yl)-ethyl-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione; Bmax; maximal number of binding sites; BRL 44408; 2-(
The peripheral benzodiazepine receptor (Translocator protein 18Â kDa) in microglia: From pathology to imaging
Keywords: [11C]; Carbon-11 isotope; [3H]; tritium isotope; AD; Alzheimer's disease; AIDS; acquired immunodeficiency syndrome; ANT; adenine nucleotide transporter; Aβ; amyloid beta; Bmax; maximal bound receptors; BP; binding potential; CD 4+ T cell; cluster of diff
Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice
Keywords: mAChR; muscarinic acetylcholine receptor; CNS; central nervous system; WT; wild type; KO; knockout; [3H]NMS; [N-methyl-3H]scopolamine methyl chloride; Kd; apparent dissociation constant; Bmax; maximal number of binding sites; Neurotransmitters, modulators
Arsenite binding to synthetic peptides based on the Zn finger region and the estrogen binding region of the human estrogen receptor-α
Keywords: BAL; 2,3-dimercaptopropanol; Bmax; maximum binding capacity; DMA(V); dimethylarsinic acid; DMA(III); dimethylarsinous acid; (FITC); fluoresceinisothiocyanate; GSAO; 4-(N-(S-gluthionylacetyl)amino)phenylarsenoxide; Kd; dissociation equilibrium constant; MM
Platelet serotonin uptake and paroxetine binding among allelic genotypes of the serotonin transporter in alcoholics
Keywords: 5-HT; serotonin; 5-HTT; serotonin transporter; 5â²-HTTLPR; serotonin transporter-linked polymorphic region; ANOVA; analysis of variance; Bmax; maximum specific paroxetine binding density; [123I]β-CIT; [123I]2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropa
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives
Keywords: Muscarinic agonist; Subtype selectivity; Dioxolane derivative; Oxathiolane derivative; Binding studies; Functional studies; CHO; Chinese hamster ovary; hm1-hm5; human muscarinic subtypes; M1-M5; muscarinic subtypes; Ki; inhibitor equilibrium dissociat
Pharmacological profiles of recombinant and native insect nicotinic acetylcholine receptors
Keywords: Drosophila; Epibatidine; Hybrid nicotinic receptor of Drosophila α2 or Myzus α2 and rat β2 subunits; Imidacloprid; Neonicotinoids; α-BGT; α-bungarotoxin; Bmax; maximal binding capacity; CLO; clothianidin; Dα2/Rβ2; hybrid receptor consisting of Dros
Characterization of 16 human G protein-coupled receptors expressed in baculovirus-infected insect cells
Keywords: G protein-coupled receptor; Protein structure; Expression; Baculovirus; Bmax;