کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6278861 1615065 2016 21 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Secretion of full-length tau or tau fragments in a cell culture model
ترجمه فارسی عنوان
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موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Tau is a microtubule-associated protein that plays an important role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease. Several studies have suggested that tau may be secreted to extracellular medium and may be responsible of spreading of neurodegeneration. The overexpression of tau in cultured non-neuronal cells leads to the secretion of this protein. The proline-rich region of tau may serve as a membrane-binding site during the secretion of the full-length tau molecule. Tau fragments lacking this proline-region are either not secreted or are secreted in a distinct manner to the full-length molecule.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 634, 10 November 2016, Pages 63-69
نویسندگان
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