کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6279300 | 1615077 | 2016 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of IL18-607CÂ >Â A and IL18-137GÂ >Â C promoter polymorphisms in antidepressant treatment phenotypes: A preliminary report
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The role of IL18-607CÂ >Â A and IL18-137GÂ >Â C promoter polymorphisms in antidepressant treatment phenotypes: A preliminary report The role of IL18-607CÂ >Â A and IL18-137GÂ >Â C promoter polymorphisms in antidepressant treatment phenotypes: A preliminary report](/preview/png/6279300.png)
چکیده انگلیسی
Recent studies suggest that immune activation and cytokines, such as IL-18, are involved in depression. IL-18 is expressed in brain and is increased in patients with moderate to severe depression. In this study we aim to evaluate the role of IL18-607C > A and IL18-137G > C promoter polymorphisms in antidepressant treatment phenotypes, specifically relapse and treatment resistant depression (TRD). We genotyped the referred polymorphisms in a subset of 80 MDD patients followed at Hospital Magalhães Lemos, Portugal, within a period of 27 months. Patients carrying IL18-607 CA or AA genotypes were significantly more prone to relapse after AD treatment and present a significantly lower time to relapse than patients carrying CC genotype. Similarly, patients carrying IL18-137 GC or CC genotypes have a significantly higher risk of relapse and display relapse significantly earlier than the ones carrying GG genotype. Due to the low number of IL18-607 CC and IL18-137 GG in the relapse subgroup (n = 3 and n = 5, respectively), results were validated by bootstrapping analysis, and remained significant. No association was found between the evaluated genetic polymorphisms and TRD. IL18 peripheral mRNA levels were upregulated in IL18-607 CA or AA carriers. This preliminary report indicates that IL18-607C > A and IL18-137G > C genetic polymorphisms seem to influence depression relapse after antidepressant treatment in our subset of depressed patients, and may possibly contribute to the disregulated IL-18 levels found in patients with depression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 622, 27 May 2016, Pages 107-112
Journal: Neuroscience Letters - Volume 622, 27 May 2016, Pages 107-112
نویسندگان
Marlene Santos, Serafim Carvalho, LuÃs Lima, Jorge Mota-Pereira, Paulo Pimentel, Dulce Maia, Diana Correia, Sofia Gomes, Agostinho Cruz, Rui Medeiros,