کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6279851 1615084 2016 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Betaine reverses the memory impairments in a chronic cerebral hypoperfusion rat model
ترجمه فارسی عنوان
بتایین اختلالات حافظه را در یک مدل موشهای هیپرپرفیژن مغزی مزمن معکوس می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Vascular dementia (VaD) is the second reason for the cognitive decline in aged people, but the effective therapy is still missing. The chronic cerebral hypoperfusion (CCH) had been widely found in VaD patients and is thought to be the key reason for cognitive impairment. Betaine is a natural product that had been implicated in many biological processes and had been used for the therapy of some neurodegenerative disease, such as Alzheimer's disease. In this study, we reported that betaine treatment could rescue the memory deficits induced by two-vessel occlusion (2-VO), a widely used CCH rat model. Betaine also restored the expression of PSD93, PSD95 and MAP2 to preserve the synaptic functions. Furthermore, betaine could reduce the oxidative stress by suppressing the MDA and ROS and enhancing the SOD and GSH. Overall, betaine treatment is able to rescue the memory deficits in CCH rats, which provide an experimental basis for the therapy of VaD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 615, 26 February 2016, Pages 9-14
نویسندگان
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