کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6280148 | 1615085 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The antinociceptive effects of a δ-opioid receptor agonist in mice with painful diabetic neuropathy: Involvement of heme oxygenase 1
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کلمات کلیدی
DPDPEMORHO-1cobalt protoporphyrin IXSTZCORM-2Heme oxygenasesCoPPSnPP - SNPPδ-Opioid receptor - δ-گیرنده اپیوئیدμ-Opioid receptor - μ-گیرنده اپیوئیدstreptozotocin - استرپتوزوتوسینDiabetes - بیماری قندAnalgesia - بیهوشیDOR - دردPain - دردcarbon monoxide - منوکسیدکربنtin protoporphyrin IX - پروتوپورفیرین IXOpioid receptors - گیرنده های اپیدمی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The antinociceptive effects of a δ-opioid receptor agonist in mice with painful diabetic neuropathy: Involvement of heme oxygenase 1 The antinociceptive effects of a δ-opioid receptor agonist in mice with painful diabetic neuropathy: Involvement of heme oxygenase 1](/preview/png/6280148.png)
چکیده انگلیسی
Our results demonstrated that the subcutaneous administration of DPDPE inhibited the mechanical and thermal allodynia as well as the thermal hyperalgesia induced by diabetes in a dose-dependent manner. Moreover, while the antinociceptive effects produced by a low dose of DPDPE were enhanced by CORM-2 or CoPP co-treatments, the inhibitory effects produced by a high dose of DPDPE were completely reversed by the administration of an HO-1 inhibitor, SnPP, indicating the involvement of HO-1 in the antinociceptive effects produced by this DOR agonist during diabetic neuropathic pain in mice. In conclusion, this study shows that the administration of CORM-2 or CoPP combined with a DOR agonist could be an interesting strategy for the treatment of painful diabetic neuropathy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 614, 12 February 2016, Pages 49-54
Journal: Neuroscience Letters - Volume 614, 12 February 2016, Pages 49-54
نویسندگان
SÃlvia Castany, Mireia Carcolé, Sergi Leánez, Olga Pol,