کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6280148 | 1615085 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The antinociceptive effects of a δ-opioid receptor agonist in mice with painful diabetic neuropathy: Involvement of heme oxygenase 1
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کلمات کلیدی
DPDPEMORHO-1cobalt protoporphyrin IXSTZCORM-2Heme oxygenasesCoPPSnPP - SNPPδ-Opioid receptor - δ-گیرنده اپیوئیدμ-Opioid receptor - μ-گیرنده اپیوئیدstreptozotocin - استرپتوزوتوسینDiabetes - بیماری قندAnalgesia - بیهوشیDOR - دردPain - دردcarbon monoxide - منوکسیدکربنtin protoporphyrin IX - پروتوپورفیرین IXOpioid receptors - گیرنده های اپیدمی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Our results demonstrated that the subcutaneous administration of DPDPE inhibited the mechanical and thermal allodynia as well as the thermal hyperalgesia induced by diabetes in a dose-dependent manner. Moreover, while the antinociceptive effects produced by a low dose of DPDPE were enhanced by CORM-2 or CoPP co-treatments, the inhibitory effects produced by a high dose of DPDPE were completely reversed by the administration of an HO-1 inhibitor, SnPP, indicating the involvement of HO-1 in the antinociceptive effects produced by this DOR agonist during diabetic neuropathic pain in mice. In conclusion, this study shows that the administration of CORM-2 or CoPP combined with a DOR agonist could be an interesting strategy for the treatment of painful diabetic neuropathy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 614, 12 February 2016, Pages 49-54
Journal: Neuroscience Letters - Volume 614, 12 February 2016, Pages 49-54
نویسندگان
SÃlvia Castany, Mireia Carcolé, Sergi Leánez, Olga Pol,