کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6280292 1615090 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluating the relationship between reelin gene variants (rs7341475 and rs262355) and schizophrenia: A meta-analysis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Evaluating the relationship between reelin gene variants (rs7341475 and rs262355) and schizophrenia: A meta-analysis
چکیده انگلیسی
Studies have suggested that reelin (RELN) polymorphism was associated with the susceptibility of schizophrenia (SZ), but the results remained controversial. Thus, we conducted this meta-analysis to determine whether RELN variants (rs7341475 and rs262355) were associated with SZ risk. Studies were identified through retrieving Web of Science, PubMed and Embase databases from inception to May 2015. The genotype data were extracted to calculate the odds ratios (ORs) and 95% confidence intervals (CIs). For rs7341475, five studies with 4741 SZ patients and 10075 controls are included and the results indicate that carriage of A allele is associated with decreased SZ risk in dominant genetic model (OR = 0.90, 95%CI = 0.83-0.98) and additive model (OR = 0.90, 95% CI = 0.84-0.97). Subgroup analysis indicates that the association between rs7341475 and SZ is only significant in Caucasian. For rs262355, four studies with 2017 SZ patients and 3274 controls are included, the results demonstrate that carriage of A allele is associated with increased risk of SZ only in Caucasian (dominant model: OR = 1.17, 95%CI = 1.01-1.37; additive model OR = 1.13, 95%CI = 1.02-1.27). This meta-analysis suggests that rs7341475 (A/G) and rs262355 (A/T) polymorphisms in RELN gene are inversely associated with SZ risk.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 609, 16 November 2015, Pages 42-47
نویسندگان
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