کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6282490 1615141 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of whiskers in compensation of visual deficit in a mouse model of retinal degeneration
ترجمه فارسی عنوان
نقش ساندویچ در جبران کسری بصری در یک مدل ماوس دژنراسیون شبکیه
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- In the seeing mice, the removal of the whiskers had no effect.
- In the blind mice, whiskers are essential for the compensation of the visual deficit.
- Both chronic and acute tactile deprivation induced anxiety-like behaviour.
- A combination of blindness and chronic tactile deprivation enhances hearing.

Sensory deprivation in one modality can enhance the development of the remaining modalities via mechanisms of synaptic plasticity. Mice of the C3H strain suffer from RD1 retinal degeneration that leads to visual impairment at weaning age. We examined a role of whiskers in compensation of the visual deficit. In order to differentiate the contribution of the whiskers from other mechanisms that can take part in the compensation, we investigated the effect of both chronic and acute tactile deprivation. Three-month-old mice were used. We examined motor skills (rotarod, beam walking test), gait control (CatWalk system), spontaneous motor activity (open field) and CNS excitability to an acoustic stimulus for assessment of compensatory changes in auditory system (audiogenic epilepsy). In the sighted mice, the only effect was a decline in their rotarod test performance after acute whisker removal. In the blind animals, chronic tactile deprivation caused changes in their gait and impaired the performance in motor tests. Some other compensatory mechanisms were involved but the whiskers are essential for the compensation as it emerged from more marked change of gait and the worsening of the motor performance after the acute whisker removal. Both chronic and acute tactile deprivation induced anxiety-like behaviour. Only a combination of blindness and chronic tactile deprivation led to an increased sense of hearing.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 558, 13 January 2014, Pages 149-153
نویسندگان
, , , ,