کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6282522 | 1615142 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Meditation's impact on default mode network and hippocampus in mild cognitive impairment: A pilot study
ترجمه فارسی عنوان
تأثیر مدیتیشن در شبکه حالت پیش فرض و هیپوکامپ در اختلال شناختی خفیف: یک مطالعه آزمایشی
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کلمات کلیدی
CDRBIDMCADAS-Cogmini-mental status examMBSRMPFCMMSEDMNROIPCCmild cognitive impairment - اختلال شناختی خفیفClinical Dementia Rating - امتیاز دهی بالینیAlzheimer's disease - بیماری آلزایمرfMRI - تصویرسازی تشدید مغناطیسی کارکردیdefault mode network - شبکه حالت پیش فرضposterior cingulate cortex - قشر ساقه خلفیmedial prefrontal cortex - قشر غده پروسترولmeditation - مدیتیشنBeth Israel Deaconess Medical Center - مرکز پزشکی بیثسی سایکونسregion of interest - منطقه مورد نظرMCI - همراه اولHippocampus - هیپوکامپ Mindfulness Based Stress Reduction - کاهش استرس مبتنی بر ذهنیت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Those with high baseline stress levels are more likely to develop mild cognitive impairment (MCI) and Alzheimer's Disease (AD). While meditation may reduce stress and alter the hippocampus and default mode network (DMN), little is known about its impact in these populations. Our objective was to conduct a “proof of concept” trial to determine whether Mindfulness Based Stress Reduction (MBSR) would improve DMN connectivity and reduce hippocampal atrophy among adults with MCI. 14 adults with MCI were randomized to MBSR vs. usual care and underwent resting state fMRI at baseline and follow-up. Seed based functional connectivity was applied using posterior cingulate cortex as seed. Brain morphometry analyses were performed using FreeSurfer. The results showed that after the intervention, MBSR participants had increased functional connectivity between the posterior cingulate cortex and bilateral medial prefrontal cortex and left hippocampus compared to controls. In addition, MBSR participants had trends of less bilateral hippocampal volume atrophy than control participants. These preliminary results indicate that in adults with MCI, MBSR may have a positive impact on the regions of the brain most related to MCI and AD. Further research with larger sample sizes and longer-follow-up are needed to further investigate the results from this pilot study.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 556, 27 November 2013, Pages 15-19
Journal: Neuroscience Letters - Volume 556, 27 November 2013, Pages 15-19
نویسندگان
Rebecca Erwin Wells, Gloria Y. Yeh, Catherine E. Kerr, Jennifer Wolkin, Roger B. Davis, Ying Tan, Rosa Spaeth, Robert B. Wall, Jacquelyn Walsh, Ted J. Kaptchuk, Daniel Press, Russell S. Phillips, Jian Kong,