کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6282874 1615148 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chronic ketamine produces altered distribution of parvalbumin-positive cells in the hippocampus of adult rats
ترجمه فارسی عنوان
کتامین مزمن توزیع تغییر یافته سلول های مثبت پرولاوبومین را در هیپوکامپ موش بالغ تولید می کند
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Ketamine SC at 8 mg/kg impaired spatial learning consistent with previous findings.
- Ketamine induced a significant increase in the number of PV+ neurons in CA3 field of hippocampus.
- Ketamine induced a significant increase in PV+ neurons outside the SO of the hippocampus.

The underlying mechanisms of schizophrenia pathogenesis are not well understood. Increasing evidence supports the glutamatergic hypothesis that posits a hypofunction of the N-methyl d-aspartate (NMDA) receptor on specific gamma amino-butyric acid (GABA)-ergic neurons may be responsible for the disorder. Alterations in the GABAergic system have been observed in schizophrenia, most notably a change in the expression of parvalbumin (PV) in the cortex and hippocampus. Several reports also suggest abnormal neuronal migration may play a role in the etiology of schizophrenia. The current study examined the positioning and distribution of PV-positive cells in the hippocampus following chronic treatment with the NMDA receptor antagonist ketamine. A robust increase was found in the number of PV-positive interneurons located outside the stratum oriens (SO), the layer where most of these cells are normally localized, as well as an overall numerical increase in CA3 PV cells. These results suggest ketamine leads to an abnormal distribution of PV-positive cells, which may be indicative of aberrant migratory activity and possibly related to the Morris water maze deficits observed. These findings may also be relevant to alterations observed in schizophrenia populations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 550, 29 August 2013, Pages 69-74
نویسندگان
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