کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6283334 | 1615156 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice
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کلمات کلیدی
TNFRTRAFTRADDRIP1inflammation - التهاب( توروم) tumor necrosis factor-α - تومور نکروز عامل αHemorrhage - خونریزیintracerebral hemorrhage - خونریزی داخل مغزیBBB - سد خونی مغزیBlood–brain barrier - سد خونی مغزیStroke - سکته مغزیtumor necrosis factor receptor associated factor - عوامل مرتبط با گیرنده فاکتور نکروز تومورTNF-α - فاکتور نکروز توموری آلفاICH - منEdema - ورمreceptor interacting protein 1 - پروتئین گیرنده گیرنده 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Intracerebral hemorrhage (ICH), the most common form of hemorrhagic stroke, exhibits the highest acute mortality and the worst long-term prognosis of all stroke subtypes. Unfortunately, treatment options for ICH are lacking due in part to a lack of feasible therapeutic targets. Inflammatory activation is associated with neurological deficits in pre-clinical ICH models and with patient deterioration after clinical ICH. In the present study, we tested the hypothesis that R-7050, a novel cell permeable triazoloquinoxaline inhibitor of the tumor necrosis factor receptor (TNFR) complex, attenuates neurovascular injury after ICH in mice. Up to 2Â h post-injury administration of R-7050 significantly reduced blood-brain barrier opening and attenuated edema development at 24Â h post-ICH. Neurological outcomes were also improved over the first 3 days after injury. In contrast, R-7050 did not reduce hematoma volume, suggesting the beneficial effects of TNFR inhibition were downstream of clot formation/resolution. These data suggest a potential clinical utility for TNFR antagonists as an adjunct therapy to reduce neurological injury and improve patient outcomes after ICH.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 542, 10 May 2013, Pages 92-96
Journal: Neuroscience Letters - Volume 542, 10 May 2013, Pages 92-96
نویسندگان
Melanie D. King, Cargill H. Jr., Krishnan M. Dhandapani,