کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6283338 | 1615156 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acute effects of resveratrol to enhance cocaine-induced dopamine neurotransmission in the striatum
ترجمه فارسی عنوان
اثرات حاد از رزوراترول جهت افزایش انتقال عصبی دوپامین ناشی از کوکائین در استریاتوم
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کلمات کلیدی
Sirt1monoamine oxidase-ACaMKKβSIRT2MAO-BDARPP-32pKaMAO-APDEERKAMPKSDSHDACsAMP-activated protein kinase - AMP-پروتئین کیناز فعال شده استStriatum - استریاتومtyrosine hydroxylase - تیروزین هیدروکسیلازDopamine - دوپامینResveratrol - رسوراترولsodium dodecyl sulfate - سدیم دودسیل سولفاتPhosphodiesterases - فسفودی استرازmonoamine oxidase-B - مونوآمین اکسیداز-Bmonoamine oxidase - مونوآمین اکسیدازها NAD - نادانNAD, nicotinamide adenine dinucleotide - نیکوتینامید آدنین دینوکلئوتیدhistone deacetylases - هیستون deacetylasesprotein kinase A - پروتئین کیناز ACocaine - کوکائین extracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Resveratrol is known as an activator of SIRT1, which leads to the deacetylation of histone and non-histone protein substrates, but also has other pharmacological profiles such as the inhibition of monoamine oxidase (MAO)-A and MAO-B. Resveratrol was previously demonstrated to potentiate the rewarding effects of chronic cocaine via activation of SIRT1. However, the role of resveratrol in cocaine responses in the acute phase remains unexplored. Therefore, we investigated the acute effects of resveratrol on cocaine-stimulated dopamine neurotransmission by analyzing protein phosphorylation in neostriatal slices. Treatment with resveratrol (50 μM for 30 min) enhanced cocaine-induced increases in the phosphorylation of DARPP-32 at Thr34 and GluA1 at Ser845, postsynaptic substrates for dopamine/D1 receptor/PKA signaling, and a cocaine-induced decrease in the phosphorylation of tyrosine hydroxylase at Ser40, a presynaptic substrate for dopamine/D2 receptor signaling. The inhibition of both MAO-A and MAO-B by clorgyline and pargyline, respectively, enhanced the effects of cocaine on DARPP-32 phosphorylation. The acute effect of resveratrol on cocaine-induced DARPP-32 phosphorylation was occluded with inhibition of MAO-A and MAO-B. In behavioral studies, resveratrol (40 mg/kg, s.c.) enhanced the increase in locomotor activity induced by acute cocaine administration (10 mg/kg, i.p.). Thus, this study provides pharmacological evidence that acute resveratrol enhances cocaine-induced dopamine neurotransmission and behavioral responses, presumably via mechanisms involving the inhibition of dopamine catabolism by MAO-A and MAO-B. Resveratrol may be useful to treat dysregulated dopamine neurotransmission, but it may enhance the risk of developing drug addiction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 542, 10 May 2013, Pages 107-112
Journal: Neuroscience Letters - Volume 542, 10 May 2013, Pages 107-112
نویسندگان
Takahide Shuto, Mahomi Kuroiwa, Yuki Koga, Yukie Kawahara, Naoki Sotogaku, Koji Toyomasu, Akinori Nishi,