کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6283601 | 1615164 | 2013 | 5 صفحه PDF | دانلود رایگان |

Occlusal disharmony is associated with increased plasma corticosterone levels, learning deficits, and morphologic alterations in the hippocampus via chronic stress. Here, we investigated the occlusal disharmony-induced impairment of hippocampal function. We first examined the effects of raising the bite on newborn cell proliferation in the hippocampal dentate gyrus (DG) in senescence-accelerated prone mice. Raising the bite significantly decreased cell proliferation in the hippocampal DG in an age-dependent manner. Immediately after raising the bite, cell proliferation decreased abruptly in the aged mice, then gradually increased, but did not recover to control levels within 2Â wk. Further, learning-induced cell proliferation was impaired in aged bite-raised mice. These findings suggest that occlusal disharmony induced by raising the bite impaired cell proliferation in the hippocampal DG, leading to learning deficits.
⺠Effects of bite-raising on hippocampalcell proliferation are not known. ⺠Raising the bite suppresses cell proliferation in the hippocampus. ⺠Cell proliferation in bite-raised mice did not recover control levels within 2 wk. ⺠Raising the bite blocked increases in learning-induced cell proliferation. ⺠Bite-raising suppressed of cell proliferation, leading to spatial learning deficits.
Journal: Neuroscience Letters - Volume 534, 8 February 2013, Pages 228-232