کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6283601 1615164 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Occlusal disharmony leads to learning deficits associated with decreased cellular proliferation in the hippocampal dentate gyrus of SAMP8 mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Occlusal disharmony leads to learning deficits associated with decreased cellular proliferation in the hippocampal dentate gyrus of SAMP8 mice
چکیده انگلیسی

Occlusal disharmony is associated with increased plasma corticosterone levels, learning deficits, and morphologic alterations in the hippocampus via chronic stress. Here, we investigated the occlusal disharmony-induced impairment of hippocampal function. We first examined the effects of raising the bite on newborn cell proliferation in the hippocampal dentate gyrus (DG) in senescence-accelerated prone mice. Raising the bite significantly decreased cell proliferation in the hippocampal DG in an age-dependent manner. Immediately after raising the bite, cell proliferation decreased abruptly in the aged mice, then gradually increased, but did not recover to control levels within 2 wk. Further, learning-induced cell proliferation was impaired in aged bite-raised mice. These findings suggest that occlusal disharmony induced by raising the bite impaired cell proliferation in the hippocampal DG, leading to learning deficits.

► Effects of bite-raising on hippocampalcell proliferation are not known. ► Raising the bite suppresses cell proliferation in the hippocampus. ► Cell proliferation in bite-raised mice did not recover control levels within 2 wk. ► Raising the bite blocked increases in learning-induced cell proliferation. ► Bite-raising suppressed of cell proliferation, leading to spatial learning deficits.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 534, 8 February 2013, Pages 228-232
نویسندگان
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