کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6283670 | 1615163 | 2013 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Circadian expression and specific localization of a sialyltransferase gene in the suprachiasmatic nucleus Circadian expression and specific localization of a sialyltransferase gene in the suprachiasmatic nucleus](/preview/png/6283670.png)
Polysialic acids are implicated in various biological processes such as neural cell migration, axonal growth, synaptogenesis and resetting of the circadian rhythm. Recently, polysialation has been reported to be involved in the formation and resetting of the circadian clock. However, the genes that control the circadian rhythm of polysialation have not been elucidated. In the present study, we investigated the expression profile of ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 (ST8Sia VI) in the suprachiasmatic nucleus (SCN), which is one of the modification transferases that add sialic acids to type O carbohydrate chains. ST8Sia VI mRNA showed strong expression in the SCN with dynamic circadian rhythm. Further, the amount of ST8Sia VI mRNA in the SCN was increased by brief light exposure. Interestingly, the localization of ST8Sia VI mRNA in the SCN differs from those of arginine vasopressin and vasoactive intestinal peptide mRNAs, which are typical SCN subregion markers showing shell and core, dorsomedial and ventrolateral, or light-responsive and unresponsive regions, respectively. The present findings suggest that ST8siVI is involved in rhythmic polysialation in the SCN and that ST8siVI expression provides a novel compartmentation of the mammalian circadian center.
⺠The SCN expresses ST8Sia VI intently as well as the hippocampus. ⺠ST8Sia VI mRNA showed a circadian rhythm in the SCN with the peak during the day. ⺠ST8Sia VI mRNA was increased by a brief light exposure during the subjective night. ⺠ST8sia VI expression provides a compartmentation of the mammalian circadian center.
Journal: Neuroscience Letters - Volume 535, 22 February 2013, Pages 12-17