c-Jun N-terminal phosphorylation is essential for hippocampal synaptic plasticity

► The synaptic role of c-Jun phosphorylation was studied in c-Jun alanine mutant mice, c-JunAA. ► c-JunAA animals show normal hippocampal structure and basal synaptic transmission. ► LTP induction was impaired in c-JunAA mice, whereas LTD induction was normal.