Overexpression of TDP-43 causes partially p53-dependent G2/M arrest and p53-independent cell death in HeLa cells

► The TDP-43 dysregulation in non-neuronal cells may contribute to the pathogenesis of ALS and FTLD. ► Overexpression of TDP-43 causes G2/M accumulation and death in non-neuronal cells. ► TDP-43-induced G2/M arrest is partly p53-dependent and death is p53-independent in HeLa cells.