The involvement of down-regulation of Cdh1-APC in hippocampal neuronal apoptosis after global cerebral ischemia in rat

► Cdh1 in hippocampus was down-regulated after global cerebral ischemia. ► The downstream substrates of Cdh1-APC were up-regulated after brain ischemia. ► The down-regulation of Cdh1-APC activity was involved in neuronal apoptosis.