Protective effects of catalpol on oligodendrocyte death and myelin breakdown in a rat model of chronic cerebral hypoperfusion

► Catalpol protects against white matter lesions after chronic cerebral hypoperfusion. ► The protective effects of catalpol are associated with its anti-apoptotic mechanism. ► Catalpol upregulates the expression of p-CREB and Bcl-2 after chronic ischemia.