Vulnerability to nicotine abstinence-related social anxiety-like behavior: Molecular correlates in neuropeptide Y, Y2 receptor and corticotropin releasing factor

▶ Nicotine trained HRs exhibited abstinence-induced social anxiety-like behavior. ▶ A chronic intermittent nicotine regimen resulted in increased CRF in CeA in HRs. ▶ NPY levels decreased in amygdala and hippocampus in nicotine trained HRs. ▶ Hippocampal Y2 receptor levels were upregulated in nicotine trained HRs.