Serum brain-derived neurotrophic factor and clozapine daily dose in patients with schizophrenia: A positive correlation

► Brain-derived neurotrophic factor (BDNF) plays a critical role in neurodevelopment and neuroplasticity. ► Clozapine (CLZ) has been shown a beneficial effect on cognition in SZ. ► Serum BDNF levels were significantly correlated with CLZ daily dose (r = 0.394, p = 0.028). ► These data support the growing body of evidence regarding the modulating effect of CLZ on cognition. ► This study suggests that serum BDNF levels are correlated with CLZ daily dose.