کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6286272 | 1615301 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A putative role of p53 pathway against impulse noise induced damage as demonstrated by protection with pifithrin-alpha and a Src inhibitor
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کلمات کلیدی
ECMPTKSrc inhibitorTTSPFTTdTOHCPTSABRFAKp53PBSDMSO - DMSOROS - ROSanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancePermanent threshold shift - تغییر آستانه دائمیTemporary threshold shift - تغییر آستانه موقتApoptosis - خزان یاختهایDimethyl sulfoxide - دیمتیل سولفواکسیدNoise - سر و صداouter hair cell - سلول بیرونی موPhosphate buffered saline - فسفات بافر شورextra-cellular matrix - ماتریکس خارج سلولیauditory brainstem response - پاسخ شنوایی مغزProtein tyrosine kinase - پروتئین تیروزین کینازPropidium iodide - پروتئین یدیدfocal adhesion kinase - کیناز چسبندگی کانونیReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A putative role of p53 pathway against impulse noise induced damage as demonstrated by protection with pifithrin-alpha and a Src inhibitor A putative role of p53 pathway against impulse noise induced damage as demonstrated by protection with pifithrin-alpha and a Src inhibitor](/preview/png/6286272.png)
چکیده انگلیسی
Exposure to high-level noise leads to oxidative stress and triggers apoptosis of the hair cells. This study examined whether p53, a tumor suppressor protein, is activated in the cochlea following impulse noise exposure. Inhibition of p53 with pifithrin alpha, a specific p53 inhibitor, or KX1-004, a Src-protein tyrosine kinase inhibitor, was tested to determine if p53 inhibition could reduce noise-induced hearing loss and cochlear damage. Chinchillas were pre-treated with a local administration of pifithrin alpha or KX1-004 and exposed to impulse noise. The chinchillas were assessed for threshold shift at 1 and 24Â h after the noise. At 4 or 24Â h post noise, the cochleae were removed and organs of Corti were examined to assess the damage to the cells and upregulation of p53 by the noise. Apoptosis was evident in both outer hair cells and supporting cells. Phospho-p53 (Ser 15) was upregulated 4Â h and 24Â h after the noise. KX1-004 and pifithrin alpha both decreased threshold shift and the number of missing outer hair cells. These results indicate that p53 is involved in the early stages of noise-induced cell death and inhibition of this signaling pathway is a potential protective strategy against noise-induced hearing loss.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volumes 81â82, AprilâMay 2014, Pages 30-37
Journal: Neuroscience Research - Volumes 81â82, AprilâMay 2014, Pages 30-37
نویسندگان
Anna R. Fetoni, Eric C. Bielefeld, Gaetano Paludetti, Thomas Nicotera, Donald Henderson,