کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6286406 | 1615305 | 2013 | 8 صفحه PDF | دانلود رایگان |
- We demonstrate the significant qEEG potentiation in depression by prefrontal rTMS.
- Prefrontal theta, delta and alpha band powers significantly enhanced by rTMS.
- Correlation was seen between F4_alpha power and HAMD_retardation changes by rTMS.
- Correlation was seen between F3_alpha power and WCST_cognitive changes by rTMS.
The long-lasting effects of repetitive transcranial magnetic stimulation (rTMS) on electroencephalogram (EEG) activity are not clear. We aimed to investigate the cumulative rTMS effects on EEG and clinical outcomes in patients with major depression. Twenty-five patients with medication-resistant depression underwent 10 daily rTMS sessions over the left dorsolateral prefrontal cortex. We measured resting EEG and spectrum-power before and after the rTMS course. Clinical efficacy was evaluated with the Hamilton's Depression Rating Scale (HAM-D) and Wisconsin Card Sorting Test (WCST). In an ANOVA model, including all prefrontal electrodes, post hoc analyses revealed significant time effects on the theta (F1,24Â =Â 7.89, PÂ =Â 0.010; +43%), delta (F1,24Â =Â 6.58, PÂ =Â 0.017; +26%), and alpha (F1,24Â =Â 4.64, PÂ =Â 0.042; 31%) bands without site specificity. Clinical correlations were observed between F4 alpha power increases and improvements in HAM-D retardation, F3 alpha power increases and improvements of the absolute changes in perseveration and error number on the WCST, and C3 and C4 theta power increases and improvements of the percent change in perseveration and error number on the WCST following rTMS. Consecutive prefrontal rTMS could induce long-lasting EEG potentiations beyond the aftereffects, resulting in improved cognitive and depressive symptoms.
Journal: Neuroscience Research - Volume 77, Issues 1â2, SeptemberâOctober 2013, Pages 70-77