کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6287036 | 1615567 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immune defense is the primary function associated with the differentially expressed genes in the cochlea following acoustic trauma
ترجمه فارسی عنوان
دفاع ایمنی عملکرد اصلی در ارتباط با ژنهای متفاوت بیان شده در حلزونی است که پس از آسیب آکوستیک به وجود می آید
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کلمات کلیدی
FPKMFDRIPAABRIngenuity Pathway Analysis - تجزیه و تحلیل راه Ingenuityanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceTranscriptome - ترانسکریپتومRNA-sequencing - توالی RNAKEGG یا Kyoto Encyclopedia of Genes and Genomes - دایرة المعارف ژن ها و ژنوم کیوتو Kyoto Encyclopedia of Genes and Genomes - دایره المعارف ژنتیک ژن ها و ژنوم کیوتوDAVID - دیویدNoise - سر و صداFragments per kilobase of transcript per million mapped reads - قطعه در هر کیلو بایت رونویسی در هر میلیون نقشه برداری شده استfalse discovery rate - میزان کشف کاذبauditory brainstem response - پاسخ شنوایی مغزdatabase for annotation, visualization and integrated discovery - پایگاه داده برای حاشیه نویسی، تجسم و کشف یکپارچهInner ear - گوش داخلی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
چکیده انگلیسی
Our previous RNA-sequencing analysis of the rat cochlear genes identified multiple biological processes and molecular pathways in the cochlear response to acoustic overstimulation. However, the biological processes and molecular pathways that are common to other species have not been documented. The identification of these common stress processes is pivotal for a better understanding of the essential response of the cochlea to acoustic injury. Here, we compared the RNA-sequencing data collected from mice and rats that sustained a similar, but not identical, acoustic injury. The transcriptome analysis of cochlear genes identified the differentially expressed genes in the mouse and rat samples. Bioinformatics analysis revealed a marked similarity in the changes in the biological processes between the two species, although the differentially expressed genes did not overlap well. The common processes associated with the differentially expressed genes are primarily associated with immunity and inflammation, which include the immune response, response to wounding, the defense response, chemotaxis and inflammatory responses. Moreover, analysis of the molecular pathways showed considerable overlap between the two species. The common pathways include cytokine-cytokine receptor interactions, the chemokine signaling pathway, the Toll-like receptor signaling pathway, and the NOD-like receptor signaling pathway. Further analysis of the transcriptional regulators revealed common upstream regulators of the differentially expressed genes, and these upstream regulators are also functionally related to the immune and inflammatory responses. These results suggest that the immune and inflammatory responses are the essential responses to acoustic overstimulation in the cochlea.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 333, March 2016, Pages 283-294
Journal: Hearing Research - Volume 333, March 2016, Pages 283-294
نویسندگان
Shuzhi Yang, Qunfeng Cai, R. Robert Vethanayagam, Jianmin Wang, Weiping Yang, Bo Hua Hu,