کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6287609 1615617 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های حسی
پیش نمایش صفحه اول مقاله
Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice
چکیده انگلیسی
► We investigated auditory effects of Cdh23 variants in both C57BL/6J and CBA/CaJ genetic backgrounds. ► The CBA/CaJ-derived Cdh23 allele lessens hearing loss and decreases hair cell loss in a C57BL/6J genetic background. ► The C57BL/6J-derived Cdh23 allele has no effect on hearing loss or hair cell death in a CBA/CaJ genetic background. ► Deleterious alleles at other loci in addition to Cdh23 must contribute to the accelerated hearing loss of C57BL/6J mice. ► Mice of the C57BL/6J and C57BL/6N substrains have identical hearing loss profiles.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 283, Issues 1–2, January 2012, Pages 80-88
نویسندگان
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